Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

HML II > Neoplasia > Flashcards

Neoplasia Flashcards

1
Q

Cancer associated with aniline dye

A

Bladder cancer

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Cancer associated with benzene

A

AML

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Cancer associated with arsenic

A

Skin and lung cancers

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Cancer associated with vinyl chloride

A

Hepatic angiosarcoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Cancer associated with aflatoxins

A

Hepatocellular carcinoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Cancers associated with HPV

A

Female - squamous cell carcinoma of cervix

Male - anogenital squamous papilloma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Cancers associated with EBV

A

Burkitt lymphoma
Hodgkin’s lymphoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Cancer associated with HBV

A

Hepatocellular carcinoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Cancers associated with ionizing radiation

A

Leukemias - AML and CML
Papillary thyroid cancer
Osteosarcoma
Liver angiosarcoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Cancers associated with immunodeficiency

A

Kaposi sarcoma
B-cell lymphoma
Cervical cancer (F)
Anal cancer (M)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Cancer associated with leukoplakia lesion

A

Squamous cell carcinoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Chronic inflammatory states that can cause adenocarcinoma

A

Barrett esophagus
Chronic gastritis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Cancer related to schistosomiasis

A

Bladder cancer

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Cancer related to Sjogren and Hashimoto

A

MALT lymphoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Autosomal recessive heritable cancer syndromes

A

Ataxia telangiectasia
Fanconi anemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Autosomal dominant heritable cancer syndromes

A

HNPCC
BRCA
Neurofibromatosis type I
RB
MEN2a
FAP
VHL
Li-Fraumeni syndrome

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Gene associated with FAP

A

APC

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Gene associated with Li-Fraumeni syndrome

A

TP53

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Gene associated with MEN2a

A

RET

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Cancer associated with nitrosamines

A

Intestinal type gastric carcinoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Key carcinogen in cigarette smoke

A

polycyclic aromatic hydrocarbons

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Cancer associated with naphthylamine

A

Transitional cell carcinoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Cancer causing mechanism of UV radiation

A

Forms pyrimidine dimers
Distorts DNA helix

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Part of cell cycle effected by ionizing radiation

A

Transition from G2 to M

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Cancers associated with HTLV-1
Adult T-leukemia and lymphoma
26
Genes associated with HTLV-1 related cancer
Tax and HBZ
27
Genes associated with HPV related cancer
E6 and E7
28
Function of E6 in HPV related cancer
Binds to p53 causing ubiquitination Degradation of p53 results in unregulated cell growth
29
Function of E7 in HPV related cancer
Binds to pRB, displacing E2F Results in unregulated cell growth
30
Gene associated with EBV related cancer
LMP-1
31
Cancer associated with HHV-8
Kaposi syndrome
32
Cancers associated with H pylori
Gastric cancer MALToma
33
Gene associated with H pylori related cancer
CagA
34
Most common malignancies associated with weight loss
GI Lung Lymphoma
35
Likely role of TNF-alpha in cancer cachexia
Suppress appetite and increase BMR
36
Cancer most likely to be associated with paraneoplastic syndromes
SCLC
37
Paraneoplastic syndromes associated with SCLC
Cushing syndrome SIADH Lambert-Eaton Cerebellar degeneration
38
Cancers associated with hypercalcemia paraneoplastically
Squamous cell carcinoma of lung Breast and ovarian carcinoma
39
Cancers associated with polycythemia paraneoplastically
Renal cell carcinoma Cerebellar hemangioblastoma Pheochromocytoma Hepatocellular carcinoma
40
Paraneoplastic syndromes associated with thymoma
Pure red cell aplasia Myasthenia gravis
41
Cancer associated with Trousseau syndrome paraneoplastically
Pancreatic cancer
42
Cancer associated with acanthosis nigricans
Gastric adenocarcinoma
43
Cancer associated with Leser-Trelat sign
GI adenocarcinomas
44
Cancer associated with dermatomyositis paraneoplastically
Bronchogenic carcinoma
45
Cancer associated with hypertrophic osteoarthopathy paraneoplastically
Adenocarcinoma of lung
46
Single most important prognostic factor
Metastasis in TNM staging
47
Intermediate filament related to carcinoma
Cytokeratin
48
Intermediate filament related to sarcoma
Vimentin
49
Intermediate filament related to rhabdomyosarcoma and uterine leiomyoma
Desmin
50
Intermediate filament related to pheochromocytoma and neuroblastoma
Neurofilament
51
Intermediate filament related to astrocytoma and ependymoma
Glial fibrillary acid protein (GFAP)
52
Tumor marker beta-HCG
Choriocarcinoma Germ cell tumors
53
Tumor marker calcitonin
Medullary thyroid carcinoma
54
Tumor marker catecholamines
Pheochromocytoma
55
Tumor marker chromogranin
Neuroendocrine
56
Tumor marker alpha-fetoprotein
Liver cancer Germ cell tumors
57
Tumor marker calretinin
Mesothelioma
58
Tumor marker carcinoembryonic antigen (CEA)
Colorectal cancer
59
Tumor marker immunoglobulins
Multiple myeloma Other gammopathies
60
Tumor marker CA-125
Ovarian cancer
61
Tumor marker CA19-9
Pancreatic cancer
62
Tumor marker CA15-3
Breast cancer
63
Cancer associated with RET oncogene
Sporadic medullary carcinoma of thyroid MEN-2A and -2B
64
Cancer and mutation associated with ABL oncogene
Chronic myeloid leukemia t(9;22) - ABL-BCR
65
Cancer and mutation associated with C-MYC oncogene
Burkitt lymphoma t(8;14) involving IgH
66
Cancer and mutation associated with CCND1 oncogene
Mental cell lymphoma t(11;14) involving IgH
67
Cancer involving ERBB2 (HER2) oncogene
Breast carcinoma
68
Tumor suppressor protein that inhibits RAS
GAPs
69
Tumor suppressor protein that inhibits AKT/PKB
PTEN
70
Most common neoplasms associated with pRB mutation
Retinoblastoma Osteosarcoma
71
Most frequently mutated gene in human cancers
TP53
72
Key initiators of p53 activation following DNA damage
ATM and ATR
73
Promotes MDM2 degradation and p53 stabilization
DNA damage
74
Downregulates WNT signaling pathway
APC
75
Cancer associated with loss-of-function mutation in E-cadherin
Infiltrating lobular carcinoma of breast
76
E-cadherin gene
CDH1
77
Cancer syndrome associated with RB1/Ch13 gene
Familial retinoblastoma
78
Cancer syndrome associated with TP53/Ch17q gene
Li-Fraumeni syndrome
79
Cancer syndrome associated with p16/INK4a gene
Familial melanoma Familial pancreatic carcinoma
80
Cancer syndrome associated with APC/Ch5q gene
FAP
81
Cancer syndrome associated with BRCA 1 and 2 genes
Familial breast and ovarian cancers
82
Function of protein affected in BRCA mutation
Repair double stranded breaks in DNA
83
Cancer syndrome associated with NF1/Ch17[ gene
Neurofibromatosis type 1
84
Cancer syndrome associated with NF2/Ch22 gene
Neurofibromatosis type II
85
Cancer syndrome associated with VHL/Ch3
Von-Hippel Lindau syndrome
86
Cancer syndrome associated with WT1/Ch11 gene
Familial Wilms tumor
87
Cancer syndrome associated with MSH-2 and-6/MLH1
Hereditary non-polyposis colorectal cancer (Lynch syndrome)
88
Result of defect in the nucleotide excision repair to replace pyrimidine dimers resulting from UVB
Xeroderma pigmentosa
89
Result of defect in ATM gene encoding a kinase that activates p53
Ataxia telangiectasia
90
Chromosomal translocation and gene associated with follicular lymphoma
t(14;18) BCL2
91
Chromosomal translocation and gene associated with Burkitt lymphoma
t(8;14) C-MYC
92
Chromosomal translocation and gene associated with DLBC lymphoma
t(3;14) BCL6
93
Chromosomal translocation and gene associated with mental cell lymphoma
t(11;14) CCND1
94
Chromosomal translocation and gene associated with CML
t(9;22) BCR-ABL
95
Chromosomal translocation and gene associated with acute promyelocytic leukemia
t(15;17) RARA-PML
96
Chromosomal translocation and gene associated with Ewing sarcoma
t(11;22) EWS-FLI1

HML II (15 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions