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HML II > Neoplasia > Flashcards

Neoplasia Flashcards

1
Q

Cancer associated with aniline dye

A

Bladder cancer

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2
Q

Cancer associated with benzene

A

AML

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3
Q

Cancer associated with arsenic

A

Skin and lung cancers

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4
Q

Cancer associated with vinyl chloride

A

Hepatic angiosarcoma

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5
Q

Cancer associated with aflatoxins

A

Hepatocellular carcinoma

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6
Q

Cancers associated with HPV

A

Female - squamous cell carcinoma of cervix

Male - anogenital squamous papilloma

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7
Q

Cancers associated with EBV

A

Burkitt lymphoma
Hodgkin’s lymphoma

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8
Q

Cancer associated with HBV

A

Hepatocellular carcinoma

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9
Q

Cancers associated with ionizing radiation

A

Leukemias - AML and CML
Papillary thyroid cancer
Osteosarcoma
Liver angiosarcoma

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10
Q

Cancers associated with immunodeficiency

A

Kaposi sarcoma
B-cell lymphoma
Cervical cancer (F)
Anal cancer (M)

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11
Q

Cancer associated with leukoplakia lesion

A

Squamous cell carcinoma

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12
Q

Chronic inflammatory states that can cause adenocarcinoma

A

Barrett esophagus
Chronic gastritis

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13
Q

Cancer related to schistosomiasis

A

Bladder cancer

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14
Q

Cancer related to Sjogren and Hashimoto

A

MALT lymphoma

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15
Q

Autosomal recessive heritable cancer syndromes

A

Ataxia telangiectasia
Fanconi anemia

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16
Q

Autosomal dominant heritable cancer syndromes

A

HNPCC
BRCA
Neurofibromatosis type I
RB
MEN2a
FAP
VHL
Li-Fraumeni syndrome

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17
Q

Gene associated with FAP

A

APC

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18
Q

Gene associated with Li-Fraumeni syndrome

A

TP53

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19
Q

Gene associated with MEN2a

A

RET

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20
Q

Cancer associated with nitrosamines

A

Intestinal type gastric carcinoma

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21
Q

Key carcinogen in cigarette smoke

A

polycyclic aromatic hydrocarbons

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22
Q

Cancer associated with naphthylamine

A

Transitional cell carcinoma

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23
Q

Cancer causing mechanism of UV radiation

A

Forms pyrimidine dimers
Distorts DNA helix

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24
Q

Part of cell cycle effected by ionizing radiation

A

Transition from G2 to M

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25
Q

Cancers associated with HTLV-1

A

Adult T-leukemia and lymphoma

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26
Q

Genes associated with HTLV-1 related cancer

A

Tax and HBZ

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27
Q

Genes associated with HPV related cancer

A

E6 and E7

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28
Q

Function of E6 in HPV related cancer

A

Binds to p53 causing ubiquitination
Degradation of p53 results in unregulated cell growth

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29
Q

Function of E7 in HPV related cancer

A

Binds to pRB, displacing E2F
Results in unregulated cell growth

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30
Q

Gene associated with EBV related cancer

A

LMP-1

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31
Q

Cancer associated with HHV-8

A

Kaposi syndrome

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32
Q

Cancers associated with H pylori

A

Gastric cancer
MALToma

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33
Q

Gene associated with H pylori related cancer

A

CagA

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34
Q

Most common malignancies associated with weight loss

A

GI
Lung
Lymphoma

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35
Q

Likely role of TNF-alpha in cancer cachexia

A

Suppress appetite and increase BMR

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36
Q

Cancer most likely to be associated with paraneoplastic syndromes

A

SCLC

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37
Q

Paraneoplastic syndromes associated with SCLC

A

Cushing syndrome
SIADH
Lambert-Eaton
Cerebellar degeneration

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38
Q

Cancers associated with hypercalcemia paraneoplastically

A

Squamous cell carcinoma of lung

Breast and ovarian carcinoma

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39
Q

Cancers associated with polycythemia paraneoplastically

A

Renal cell carcinoma
Cerebellar hemangioblastoma
Pheochromocytoma
Hepatocellular carcinoma

40
Q

Paraneoplastic syndromes associated with thymoma

A

Pure red cell aplasia
Myasthenia gravis

41
Q

Cancer associated with Trousseau syndrome paraneoplastically

A

Pancreatic cancer

42
Q

Cancer associated with acanthosis nigricans

A

Gastric adenocarcinoma

43
Q

Cancer associated with Leser-Trelat sign

A

GI adenocarcinomas

44
Q

Cancer associated with dermatomyositis paraneoplastically

A

Bronchogenic carcinoma

45
Q

Cancer associated with hypertrophic osteoarthopathy paraneoplastically

A

Adenocarcinoma of lung

46
Q

Single most important prognostic factor

A

Metastasis in TNM staging

47
Q

Intermediate filament related to carcinoma

A

Cytokeratin

48
Q

Intermediate filament related to sarcoma

A

Vimentin

49
Q

Intermediate filament related to rhabdomyosarcoma and uterine leiomyoma

A

Desmin

50
Q

Intermediate filament related to pheochromocytoma and neuroblastoma

A

Neurofilament

51
Q

Intermediate filament related to astrocytoma and ependymoma

A

Glial fibrillary acid protein (GFAP)

52
Q

Tumor marker beta-HCG

A

Choriocarcinoma
Germ cell tumors

53
Q

Tumor marker calcitonin

A

Medullary thyroid carcinoma

54
Q

Tumor marker catecholamines

A

Pheochromocytoma

55
Q

Tumor marker chromogranin

A

Neuroendocrine

56
Q

Tumor marker alpha-fetoprotein

A

Liver cancer
Germ cell tumors

57
Q

Tumor marker calretinin

A

Mesothelioma

58
Q

Tumor marker carcinoembryonic antigen (CEA)

A

Colorectal cancer

59
Q

Tumor marker immunoglobulins

A

Multiple myeloma
Other gammopathies

60
Q

Tumor marker CA-125

A

Ovarian cancer

61
Q

Tumor marker CA19-9

A

Pancreatic cancer

62
Q

Tumor marker CA15-3

A

Breast cancer

63
Q

Cancer associated with RET oncogene

A

Sporadic medullary carcinoma of thyroid

MEN-2A and -2B

64
Q

Cancer and mutation associated with ABL oncogene

A

Chronic myeloid leukemia

t(9;22) - ABL-BCR

65
Q

Cancer and mutation associated with C-MYC oncogene

A

Burkitt lymphoma

t(8;14) involving IgH

66
Q

Cancer and mutation associated with CCND1 oncogene

A

Mental cell lymphoma

t(11;14) involving IgH

67
Q

Cancer involving ERBB2 (HER2) oncogene

A

Breast carcinoma

68
Q

Tumor suppressor protein that inhibits RAS

A

GAPs

69
Q

Tumor suppressor protein that inhibits AKT/PKB

A

PTEN

70
Q

Most common neoplasms associated with pRB mutation

A

Retinoblastoma
Osteosarcoma

71
Q

Most frequently mutated gene in human cancers

A

TP53

72
Q

Key initiators of p53 activation following DNA damage

A

ATM and ATR

73
Q

Promotes MDM2 degradation and p53 stabilization

A

DNA damage

74
Q

Downregulates WNT signaling pathway

A

APC

75
Q

Cancer associated with loss-of-function mutation in E-cadherin

A

Infiltrating lobular carcinoma of breast

76
Q

E-cadherin gene

A

CDH1

77
Q

Cancer syndrome associated with RB1/Ch13 gene

A

Familial retinoblastoma

78
Q

Cancer syndrome associated with TP53/Ch17q gene

A

Li-Fraumeni syndrome

79
Q

Cancer syndrome associated with p16/INK4a gene

A

Familial melanoma
Familial pancreatic carcinoma

80
Q

Cancer syndrome associated with APC/Ch5q gene

A

FAP

81
Q

Cancer syndrome associated with BRCA 1 and 2 genes

A

Familial breast and ovarian cancers

82
Q

Function of protein affected in BRCA mutation

A

Repair double stranded breaks in DNA

83
Q

Cancer syndrome associated with NF1/Ch17[ gene

A

Neurofibromatosis type 1

84
Q

Cancer syndrome associated with NF2/Ch22 gene

A

Neurofibromatosis type II

85
Q

Cancer syndrome associated with VHL/Ch3

A

Von-Hippel Lindau syndrome

86
Q

Cancer syndrome associated with WT1/Ch11 gene

A

Familial Wilms tumor

87
Q

Cancer syndrome associated with MSH-2 and-6/MLH1

A

Hereditary non-polyposis colorectal cancer (Lynch syndrome)

88
Q

Result of defect in the nucleotide excision repair to replace pyrimidine dimers resulting from UVB

A

Xeroderma pigmentosa

89
Q

Result of defect in ATM gene encoding a kinase that activates p53

A

Ataxia telangiectasia

90
Q

Chromosomal translocation and gene associated with follicular lymphoma

A

t(14;18)
BCL2

91
Q

Chromosomal translocation and gene associated with Burkitt lymphoma

A

t(8;14)
C-MYC

92
Q

Chromosomal translocation and gene associated with DLBC lymphoma

A

t(3;14)
BCL6

93
Q

Chromosomal translocation and gene associated with mental cell lymphoma

A

t(11;14)
CCND1

94
Q

Chromosomal translocation and gene associated with CML

A

t(9;22)
BCR-ABL

95
Q

Chromosomal translocation and gene associated with acute promyelocytic leukemia

A

t(15;17)
RARA-PML

96
Q

Chromosomal translocation and gene associated with Ewing sarcoma

A

t(11;22)
EWS-FLI1

HML II (15 decks)

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