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Hematopoietic system infections Flashcards

1
Q

Pathogens infective to erythrocytes

A

Plasmodium
Babesia microti
Parvovirus B19

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2
Q

Pathogens infective to lymphocytes and lymphatics

A

HIV
EBV
CMV
Wuchereria
Brugia

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3
Q

Pathogens infective to endothelial cells

A

Rickettsia
Bartonella
Hantavirus

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4
Q

Vector for malaria

A

Female anopheles mosquito

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5
Q

Cycle of malaria in human liver

A

Exoerythrocytic cycle

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6
Q

Cycle of malaria in human RBC

A

Erythrocytic cycle

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7
Q

Infective form of malaria to humans

A

Sporozoites

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8
Q

Responsible for relapse and vivax and ovale malaria

A

Hypnozoites

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9
Q

Attachment of P falciparum in RBC

A

Erythrocyte glycophorin A

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10
Q

Membrane protein expressed with IC falciparum malaria

A

PfEMP1

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11
Q

Primary receptor of P vivax

A

Duffy chemokine receptor/Duffy blood group antigen

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12
Q

Hemozoin pigments in infected RBCs and macrophages

A

Malaria

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13
Q

Complications of P falciparum malaria

A

Cerebral malaria
Black water fever

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14
Q

Complication of P malariae malaria

A

Nephrotic syndrome

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15
Q

Complication of untreated P vivax

A

liver, kidney and brain damage

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16
Q

Single ring form in enlarged, circular RBC

A

P vivax

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17
Q

Multiple ring forms in single, unenlarged RBC with some stuck to periphery. Crescentic shaped gametocytes are seen.

A

P falciparum

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18
Q

Single ring form in an enlarged, oval RBC

A

P ovale

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19
Q

Bar and band shaped trophozoites and merozoites that form rosette in smear

A

P malariae

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20
Q

Treatment for liver stages of P vivax and P ovale

A

Primaquine

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21
Q

Primary vector of babesia microti

A

Ixodes tick

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22
Q

Endemic area of Babesia

A

Northeastern seaboard of US

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23
Q

Infective form to humans is pyriform bodies that attach to glycophorins A and B

A

Babesia microti

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24
Q

Multiple ring forms forming tetrads

A

Babesia microti

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25
Treatments for mild to moderate babesiosis
Atovaquone Azithromycin
26
Treatments for severe babesiosis
Clindamycin Exchange transfusion QuinineC
27
Complications of babesiosis in immunocompromised
Hemolytic anemia with renal failure
28
Non-enveloped, linear ssDNA virus that replicates in S phase of cell cycle
Parvovirus B19
29
Virus that targets erythroid progenitor cells in bone marrow
Parvovirus B19
30
Cell receptor for parvovirus B19
P antigen - globoside
31
Transmission of parvovirus B19
Respiratory droplets Transplacental
32
Complications of parvovirus B19
Transient aplastic crisis Hydrops fetalis
33
Enveloped, dsDNA, gamma herpesvirinae
EBV
34
Neoplasms associated with EBV
Burkitt lymphoma B cell lymphoma in AIDS Nasopharyngeal carcinoma Hodgkin's lymphoma
35
Target of EBV
Binds to CD21/CR2 on mature B cells
36
3 outcomes of EBV infection
Lytic infections - minority Latent infections - majority Stimulate growth and immortalize B cells
37
EBV encoded proteins that help establish latency
EBNA-1 LMP1 EBNA-2 VL-10
38
Function of EBNA-1 in EBV
Incorporates EBV genome into host chromosome
39
Function of LMP-1 in EBV
Drives B cell activation and proliferation by mimicking CD40 Prevents apoptosis by activating Bcl-2
40
Function of EBNA-2 in EBV
Promotes B cell activation and replication Turns on transcription for cyclin D
41
Function of VIL-10 in EBV
Inhibits macrophages, dendritic cells, and antiviral Th1 cells
42
Complications of infectious mononucleosis
Splenic rupture with minor trauma B cell lymphoma in immunocompromised
43
Poorly differentiated monoclonal B cell lymphoma of the jaw and face, seen in EBV
African Burkitt lymphoma
44
Raised, corrugated, white lesions of the tongue and mouth associated with EBV and AIDs
Hairy oral leukoplakia
45
EBV DNA in tumor cells that are of epithelial origin
Nasopharyngeal carcinoma
46
Most specific test for EBV
Rising titer of antibodies to VCA, EA, and EBNA
47
Presence of IgM antibody to VCA in EBV
Acute primary infection
48
Presence of IgG antibody to VCA, but absence of antibody to EBNA in EBV
Chronic primary infection
49
Elevation of antibodies to VCA and EA in EBV
Recovery
50
Elevated antibodies to VCA and EBNA in EBV
Past infection
51
Triad of symptoms in EBV
Lymphadenopathy Splenomegaly Exudative pharyngitis
52
Enveloped, DNA, beta herpesvirinae
CMV
53
Transmission of CMV
All body fluids, including breast milk, semen, and vaginal secretions
54
Targets of CMV
Granulocytes Bone marrow progenitors Fibroblasts Epithelial cells
55
Cells that hold latent CMV
Myeloid stem cells Monocytes Lymphocytes Stromal cells of bone marrow
56
Cytomegaly of entire cell and nucleus with a large basophilic inclusion in the nucleus with clear halo
Cytopathic effects of CMV infected cells
57
Finding of neonatal infections of CMV
IgM antibodies
58
Treatments for CMV
Ganciclovir Foscarnet Cidofovir
59
Transmission of filariasis
Mosquito bite
60
Types of filariasis
Wuchereria bancrofti Brugia malayi
61
Periodicity of filariasis
Nocturnal
62
Treatments for filariasis
Diethyl carbamazine Invermectin
63
Vector of Ehrlichia
Lone star tick
64
Complications of Ehrlichia
Fulminant septic syndrome, particularly in immunocompromised
65
Infects blood monocytes and mononuclear phagocytes in tissues and organs
Ehrlichia
66
Infects granulocytes --> neutrophils, eosinophils, and basophils
Anaplasma
67
Vector for Anaplasma
Ixodes tick
68
Severe complications of anaplasmosis
Demyelinating polyneuropathy Facial palsy
69
Specific test for ehrlichiosis
Nucleic acid amplification test (NAAT)
70
Specific test for anaplasmosis
PCR
71
Treatments for anaplasmosis and ehrlichiosis
Doxycycline Rifampin
72
Transmission of Coxiella
Zoonotic infection shed in parturition Inhalation of particles
73
Infection of macrophage after phagocytosis after phagolysosome lysis
Coxiella
74
Symptoms of chronic endocarditis with negative blood cultures
Coxiella
75
Complications of coxiella
Chronic endocarditis Granulomatous hepatitis
76
Treatment for acute coxiella
Doxycycline
77
Treatment of chronic coxiella
Hydroxychloroquine Doxycycline
78
Vector for dengue virus
Female ades aegypti mosquito
79
Flaviviridae that replicates in monocytes and macrophages
Dengue virus
80
Severe forms of dengue that can occur with reinfection with another strain
Dengue hemorrhagic fever Dengue shock syndrome
81
Test helpful for distinguishing dengue subtype
Monoclonal antibodies
82
Transmission of Rickettsia
Dermacentor tick --> dog or wood tick
83
Best stain for Rickettsia
Giemsa
84
Obligate IC parasite that multiplies in the endothelial lining of blood vessels and has OmpA
Rickettsia
85
Function of OmpA in Rickettsia
Attachment to endothelium
86
Maculopapular rash the starts on hands and feet and spreads to trunk that later becomes petechial/purpuric
Rocky mountain spotted fever
87
Complications caused by pinpoint hemorrhages in RMSF
Encephalitis Pneumonitis Cardiac arrhythmia
88
Complications of RMSF in elderly
Splenomegaly DIC Shock Death
89
Treatments for RMSF
Doxycycline Rifampin
90
Enveloped, segmented, negative sense ssRNA virus
Hantavirus/Bunyavirus
91
Transmission of hantavirus
Inhalation of aerosols released from infected deer mouse excreta
92
2 fatal diseases associated with hantavirus
Hemorrhagic fever with renal syndrome (HFRS) Hantavirus pulmonary syndrome (HPS)
93
Treatment for hantavirus
Ribavirin in early infection

HML II (15 decks)

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