Neonates Flashcards
Definition of neonate
≤28 days
Late preterm
35-36.6
Preterm
<37 weeks
extreme preterm
<30 weeks
Neonate cardiac output
Preload in the neonates is fixed with less stretch/frankstarlings law. heart is underdeveloped and won’t stretch
A decreased ability to manipulate contractility and very afterload dependant. (milironone/dobutamine)
Name the three ducts for fetal transition
- ductus venous
- formamen ovale
- ductus arteriosus
Describe cardiovascular transitional changes during delivery
- Ductus venous functionally closes soon after clamping, and structurally over days to weeks.
- Fluid in the lungs need to be absorbed to allow air into the lungs, oxygen dilates the pulmonary vasculature, decreasing PVR. Which then increases pulmonary blood flow which will increase the left atrial pressures and causes the FO to close.
- During transition the PVR decreases to or below SVR and the Right to Left shunt decreases
- The FO closes and DA beings to constrict but can remain as a bidirectional shunt for days.
8 step process for acorn
- ID neonates who are unwell
- Is immediate intervention required
- ACoRN Primary
- Infection
- Problem list
- Address problem list
- early consultation
- support family
The unwell baby
Poor tone/reflexes. Increased WOB. Poor perfusion, poor temperature, hypoglycaemia.
At risk baby
Preterm <37 weeks/SGA. Mom of DM, substance using mom, PPROM, abnormal warm/cold environment.
Central Cyanosis ethology
Respiratory in nature, CHD, increasing PVR and shunt physiology
Tx of ineffective breathing
HR < 100 effective IPPV and reassess HR. If HR 60-100 continue IPPV. If HR <60, begin CPR.
Respiratory sequence for acorn
- recheck patients airway/breathing
- administered o2 as need to maintain spo2 88-95%
- establish/continue monitors: sat, bp, cardiorespiratory, oxygen analyzer
- calculate ACoRN score if spontaneously breathing.
Resp score values (mild/mod/severe)
mild: <5
Moderate: 5-8
Severe: >8
Mild resp distress
focused hx, physical exam, review dx gets, establish working dx
Moderate resp distress
consider/adjust resp support (CPAP/PPV)
Severe resp distress
intubate, optimize ventilation. vascular access, cxr, blood gases, consider immediate consult
Define TTN
is a parnchymeal lung disorder characterized by pulmonary edema resulting from delayed resorption and clearance of fetal alveolar fluid
Define RDS
Defined primarily by deficiency of pulmonary surfactant in an immature lung.
In the premature lung, inadequate surfactant activity results in high surface tension leading to instability of the lung at end-expiration, low lung volume and decreased compliance.
Altering signs
laboured breathing (nasal flaring, grunting, intercostal retractions, sternal retractions, gasping)
- RR >60
- receiving resp support
Neonatal CVS key concepts
- Shock, cyanosis, o2 therapy or tachycardia are indictors of CVS instability
- Prostaglandin E1 is the life saving tx for ductus dependant lesions
- SVT >220
- Shock may be the initial presentation of sepsis
- The classic presentation of a ductus dependent lesion is cyanosis and/or shock
cardiovascular sequence clues
pale, mottled, or grey.
weak pulses or low bp
cyanosis unresponsive to o2
heart rate >220
cardiovascular sequence
- pale/mottled = consider IV/volume expansion
- cyanosis unresponsive to o2= perform hyperoxia test
- HR >220 = record ECG
Neonate shock tx
Hypovolemic = volume expansion Distributive = volume/inotropes/vasoconstrictors Cardiogenic= inotropes/prostaglandin
Hyperoxia Test
Ideal 15-20 minutes FiO2 of 1.0 then check PaO2 to see if there is an increase. Modifiable for spo2 >10%
Assuming a normal Hb level and adequate cardiac output, how are various degrees of desaturation (hypoxemia) tolerate?
SpO2 >75 = mild - moderate defat = well tolerated
SpO2 65-75% =marked= may be less well tolerated if baby otherwise sick
Spo2 <65= severe= poorly tolerate
Neonate severe cardiac instability
listless, or lethargic and/or distressed, decreased tone
cap refill >3s
pulses weak
gallop
edema or signs of other third space fluid
congested lungs or pleural effusions and/or enlarged heart on cxr
Neonate neurology alerting signs
abnormal tone, jitteriness, seizures
Neonate glucose <2.6
D10W bolus 2ml/kg
initiate D10W infusion at 4ml/kg/hr
Front line seizure med for neonates
phenobarbital 20mg/kg
Hx and focused investigations for Neo neuro
CBC with diff, glucose, sodium, calcium, potassium, and magnesium, blood gases, blood cultures
Perinatal brain injury
HIE
stroke
ICH
Neonate Abx
ampicillin, gentamycin, acyclovir for neonates
Neonate seizure clock
Phenobarb 20mg/kg then 10mg/kg x 2 phenytoin 20mg/kg keppra 40-60mg/kg midaz midaz infusion pyridoxine
Neonate BGL <1.8 tx
2ml/kg bolus then 4ml/kg/hr of D10w
Neonate <2.6 BGL
4ml/kg/hr of D10w
Neonate hypothermia
<36
neonate normothermia
36.3-37.2
Fluid required for 0 days
60-80ml/kg/d
fluid required for 1 day
80-100ml/kg/d
fluid required for 2 day
100-120ml/kg/d
fluid required for 3 day
120-140ml/kg/d
fluid required for 4 day
150ml/kg/d
Closure of Fontanelles
posterior 2-3m after birth
sphenoid close at 6 months
mastoid 6-18mon
anterior 12-18 months