Neonatal Hypoglycaemia Flashcards
Describe glucose and its use in the body
- Primary fuel for the body
- Brain cannot store adequate amounts so steady supply is required
What is Hypoglycaemia?
Low blood sugar; insufficient circulating glucose to meet the metabolic demands of the body
<2.6mmol/l
What is Glycogenesis?
Process by which unneeded glucose is converted to glycogen for storage
What is Glycogenolysis?
Process by which glycogen is broken down into glucose
What is Gluconeogenesis?
Production of glucose in the liver by means of non-glucose precursors such as lactate, pyruvate, glycerl and amino acids
What is insulin?
Hormone secreted by pancreatic beta cells in response to increase of plasma glucose
How does insulin regulate blood sugar?
Decreases levels by:
- Promoting glycogen formation
- Suppressing hepatic glucose
- Driving peripheral uptake of glucose
Where is glucagon produced?
Alpha cells in the pancreas
How does glucagon regulate blood sugar?
- Promotes glycogenolysis and gluconeogenesis
- Opposes effect of insulin by raising blood glucose
Describe the process if blood glucose is low
- Pancreatic alpha cells release glucagon
- Glucagon causes liver to release glucose into the blood
- Blood glucose levels increase to normal
Describe the process if blood glucose is high
- Pancreatic beta cells release insulin
- Insulin causes fat cells to take in glucose
- Blood glucose levels decrease to normal
Why should blood glucose levels not be checked within the first 2 hours of birth?
They will be low because babies use amino acids as energy immediately after birth
What are the risk factors associated with Hypoglycaemia?
- <37/40
- <2.5kg
- Born to diabetic mother
- Maternal drugs
- Sepsis
- Perinatal stress/ asphyxia
- Inborn errors of metabolism
What are the general symptoms?
- Abnormal cry
- Poor feeding
- Hypothermia
What are the cardio-respiratory symptoms?
- Tachypnoea
- Apnoea
- Cyanosis