Neonatal, Brandau Flashcards
what can cause virilization of neonate
21a hydroxylase deficiency
11b hydroxylase deficiency
neonate high low cortisol ACTH way low free T4 low TSH normal GH low FSH LH low dx?
pan pituitary problem
presentation of neonate with GH deficient
micropenis
hypoglycemia
exaggerated jaundice
clincal manifestations TSH deficiency in newborn
large fontanelle, lethargy, constipation, hoarse cry, hypotonia, hypothermia and jaundice
causes of pan anterior pituitarism
congential TB inflammation injuries lesions surgery tumor radiographic therapy
what is a 2 vessel umbilical cord
single umbilical artery
find a single umbilical artery in newborn, what should you do next?
US screen of abdomen and kidneys
differential Dx for persistant hypoglycemia
prematurity intrauterine frowth retardation infant of DM mother hypothermia perinatal asphyzia sepsis disorders of gluconeogenesis/glycogenolysis hyperinsulinism primary and secondary adrenal insufficiency congenital hypopituitarism
genetic syndromes associated with micropenis
smith lemli opitz syndrome
kallmann syndrome
prader willi syndrome
abnormalities in smith lemli opitz
microcephaly, low set ears, micrognathia
genital abnormalities 70% time
cardiac defects– endocardial most common
genital abnormalities and loss sense of smell
unilateral renal agenesis
kallmann syndrome
what is bilateral synkinesis and what syndrome is it assoc with
movement of hand mirrored by other hand
kallmann syndrome
hypotonia, failure to thrive, feeding difficulties, hypogonadism and developmental delays in newborn
prader willi
