Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

endoII exam2 > Darrow pituitary diseases part II > Flashcards

Darrow pituitary diseases part II Flashcards

1
Q

37 M weakness, lethargy, coldness, decreased libido, hair loss arthralgias RUQ pain

A

hypothyroidism

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

most common cause of increased unconj bilirubin in US

A

gilberts and other conjugation defects

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

what hormone is lost first in pituitary insufficiency

A

GH

then gnRH

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

deficiency in GH has what Sx

A

decreased muscle and bone mass, increased central fat, decreased CO, increased cholesterol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

deficiency GnRH has what Sx

A

fine wrinkling of skin, decreased libido, hair loss, gyncecomastia, atrophic testicles, vaginal dryness, alopecia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

deficiency of TSH causes what

A

fatigue, constipation, dry skin, puffiness, alopecia, cold intolerance, weight gain, increased cholesterol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

what is Queen Annes sign

A

alopecia from TSH deficiency

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

what are signs of ACTH deficiency

A

weakness, fatigue, low grade fever, orthostasis, loss of sex hair, pallor, hypoglycemia, abdominal pain, nausea, vomiting, weight loss, low Na and normal K

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

what are vascular causes of pituitary insufficiency

A

pituitary apoplexy, sheehans, ischemic strokes, DM

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

what are infectious causes of pituitary insufficiency

A

syphilis, TB, fungal, parasite

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

what are the infiltrative disorders that can cause pituitary insufficiency

A

langerhands histiocytosis, wegeners, leukemia, lymphoma, hemochromatosis, amyloid, sarcoid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

what neoplastic disorders can cause pituitary insufficiency

A

adenoma, metastasis, meningioma, optic glioma, craniopharyngioma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

what are the familial/genetic disorders that can cause pituitary insufficiency

A

kallmanns yndrome- GnRH stays in nose(loss of sense of smell), prader-willi syndrome

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

what is the autoimmune cuase of pituitary insufficiency

A

lymphocytic hypophysitis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

what type of trauma causes pituitary insufficiency

A

surgery, post CABG, head trauma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

what are the endocrine causes pituitary insufficienc

A

hypothalamic or pituitary disease like MEN1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

tests to order if suspect pituitary insufficiency

A 
PRL
GH, IGF-1
TSH, T4
testosterone, estradiol, FSH, LH
cortisol, ACTH, DHEA
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

at what level IGF-1 do you suspect GH will be low as well

A

<85 mcg/L

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

what can you use to stimulate GH

A

glucagon, insulin induced hypoglycemia, argining GHRH

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

What will TSH T4 look like in pituitary insufficiency

A

TSH tends to be normal in macroadenomas, T4 low

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

what tells you there is a GN deficiency in M

A

low total testosterone at 8 AM with non elevated LH

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

what tells you there is a GN deficiency in F

A

low estradiol with non elevated FSH

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

if cortisol is less than 3 ug at 8 AM

A

cortisol deficiency

24
Q

give ACTH and then after 45 minutes cortisol is <18 ug/dL

A

adrenal insufficiency

25
what causes the hyponatremia in pituitary insufficiency
low thyroxine and cortisol dec CO so there is increased ADH secretion cortisol normally inhibits CRH and ADH so even more ADH
26
how does pituitary insufficiency cause low BP
cortisol is needed to make epi | so without cortisol and epi there is dec BP
27
what type of hyponatremia is from hypothyroidism?
euvolemia
28
what type of hponatremia is from adrenocorticotropin deficiency
euvolemic
29
which hormones keep glucose from dropping too low
epinephrine | glucagon, cortisol and GH
30
what hormones that keep glucose from dropping too low act the fastest
epinephrine and glucagon
31
what must you do before MRI for pituitary insufficiencu
confirm with lab tests
32
how do you replace hormones in pituitary insufficiency
cortisol 1st then thyroid then testosterone and sometimes at the end GH
33
if you give someone with pituiatary insufficiency cortisol and then they have polyuria what should you suspect
DI because cortisol increases the GFR but fi there is no ADH, patient will have polyuria
34
in anterior piruirary failure with central DI what should you suspect instead
hypophysitis, metastatic cancer or sarcoidosis
35
Signs hemochromatosis
``` DM grey skin joint pain dilated CM heart rhythm disturbances high Fe:TIBC ratio elevated liver enzymes ```
36
``` F with HA has enlarged sella tursica no mesntrual abnormalities BP and sugars normal complexion and skin normal msot likely? ```
empty sella syndrome
37
F with polyuria and polydipsia craving ice water elevated Na and uric acid
DI
38
what will serum uric acid be in psychogenic polydipsia
low
39
BUN in DI and psychogenic polydipsia
low
40
desmopressin causes increase in osmolality
central DI
41
central DI on MRI
thickened pituitary stalk
42
Causes for polyuria
``` C DRIPPEd C- cortisol excess D- DI R- Recovery from Renal failure I- ions, hyper Ca and hypo K Parkinsons Psychogenic polydipsia Enzyme- autoimmune DI Drugs- lithium, demeclocycline, cis-platinum ```
43
how to calculate serum osmolality
2xNa + glucose/18 + (BUN/2.8)
44
V1 R in kidneys
cause uric acid excretion
45
initial NA levels of psychogenic polydipsia
<140 meq/L
46
what can cause thickening of pituitary stalk
lymphocytic hypophysitis(autoimmune), sarcoidosis (infiltrative diseases),
47
genetic disorder with central DI
wolfram DIDMOAD on chrom 4
48
Tx DI
desmopressin BID orally | watch for suicide
49
what is Tx for partial DI
hydrochlorothizide 50-100 mg daily
50
how does lithium look like DI
messes the collecting ducts in kidneys | "pseudo DI"
51
water restriction test will increase Uosm in what syndrome
PP
52
what will desmopressin do in lithium caused DI
nothing
53
congenital causes of nephrogenic DI
x linked defective X linked V2 R or aquaporin AQP2
54
what drugs can cause nephrogenic DI
coticosteroids
55
electrolyte imbalance caused nephrogenic DI
low K, low Mg, hyperCa
56
what drugs can cause nephrogenic DI
lithium, demeclocycline, foscarnet, methicillin, amphotericin b

endoII exam2 (18 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions