Neisseria Meningitidis

Question 1

Which GNC is glucose and maltose positive??

Answer 1

N. Meningitidis

Question 2

Non pathogenic neisseria spp grows at what temperature?

Answer 2

22°C… Others grow at 37

Question 3

Pathogenesis of meningitidis

Answer 3

Has to cross the naso pharyngeal mucosa and enter circulation.. Pilus helps with colonisation

Polysaccharide capsules protect it from host immunity

Various secretion systems helps to deliver toxins, igA protease enhances survival with epithelial cells

Question 4

What are the features of cultural investigation for meningitidis.

Answer 4

Fastidious, transparent, non hemolytic colony. Maybe mucoid if capsule is present, oxidase positive

Question 5

Csf examination for meningitidis

Answer 5

Csf has high pressure and its turbid. Csf polymorph and proteins are raised and glucose is reduced

Question 6

Which test is used to identify capsular Polysaccharide antigen in serogrouping?

Answer 6

Slide aggultination test using polyclonal antibodies

Question 7

Treatment for meningitidis

Answer 7

3rd gen cephalosporin: ceftriaxone… Later cipro is used

Question 8

Gonococci are divided into 4 kellog types by

Answer 8

Colonial appearance, ability to auto aggultinate, virulence

Question 9

Epidemiological typing of gonococci uses?

Answer 9

Auxotyping and monococcal antibodies

Question 10

What makes adult vagina resistant to gonococcal infection??

Answer 10

Low pH and stratified squamous epithelium

Question 11

Treatment of ophthalmia neonatorum??

Answer 11

Silver nitrate solution

Question 12

Treatment of N. Gonorrhoea

Answer 12

IM ceftriaxone and azythromycin

Question 13

Which serotype do pilgrims have??

Answer 13

W-135

Question 14

What is the treatment for infections caused by chlamydia??

Answer 14

Doxycyline

Question 15

What is the treatment for infections caused by trichomonas?

Answer 15

Metronidazole

Question 16

What is the treatment for infections caused by candida?

Answer 16

Clotrimazole

Question 17

What are the risk factors for meningococcal disease?

Answer 17

Age: bimodal distribution, 3mnths to 3yrs.. 18yrs to 23 yrs.

Lack of bactericidal activity.

Travel to endemic states.

Splenectomy.

Complement deficiencies.

Question 18

What are the virulence factors for N. Meningitidis

Answer 18

Nasal colonisation involving type 4 pilus.

Polysaccharide capsules that avoids host immunity.

Various secretion systems that helps to deliver toxins.

IgA protease that enhances survival within epithelial cells.

Question 19

List the clinical features of N. Meningitidis

Answer 19

Acute meningitis, septicemia, purulent conjunctivitis, pericarditis.

Chronic septicemia with joint involvement (less common)

Question 20

What are the microscopic observations for meningitidis diagnosis?

Answer 20

Gram negative intracellular Diplococci

Question 21

The meningococcal serotype involved in local outbreaks is??

Answer 21

Serotype C

Question 22

List the methods of infection control in meningitidis

Answer 22

Vaccination maybe offered.

Ciprofloxacin is recommended for all ages and in pregnant women.

Chemoprophylaxis is indicated for people who had close contact with the pt during the 7 days before illness.

Droplet infection control precautions are recommended.

Question 23

What are the vacancies used in meningitidis?

Answer 23

Group c conjugate vaccine.
Group b protein vaccine.
Quadrivalent ACWY vaccine