Neisseria Meningitidis Flashcards
Which GNC is glucose and maltose positive??
N. Meningitidis
Non pathogenic neisseria spp grows at what temperature?
22°C… Others grow at 37
Pathogenesis of meningitidis
Has to cross the naso pharyngeal mucosa and enter circulation.. Pilus helps with colonisation
Polysaccharide capsules protect it from host immunity
Various secretion systems helps to deliver toxins, igA protease enhances survival with epithelial cells
What are the features of cultural investigation for meningitidis.
Fastidious, transparent, non hemolytic colony. Maybe mucoid if capsule is present, oxidase positive
Csf examination for meningitidis
Csf has high pressure and its turbid. Csf polymorph and proteins are raised and glucose is reduced
Which test is used to identify capsular Polysaccharide antigen in serogrouping?
Slide aggultination test using polyclonal antibodies
Treatment for meningitidis
3rd gen cephalosporin: ceftriaxone… Later cipro is used
Gonococci are divided into 4 kellog types by
Colonial appearance, ability to auto aggultinate, virulence
Epidemiological typing of gonococci uses?
Auxotyping and monococcal antibodies
What makes adult vagina resistant to gonococcal infection??
Low pH and stratified squamous epithelium
Treatment of ophthalmia neonatorum??
Silver nitrate solution
Treatment of N. Gonorrhoea
IM ceftriaxone and azythromycin
Which serotype do pilgrims have??
W-135
What is the treatment for infections caused by chlamydia??
Doxycyline
What is the treatment for infections caused by trichomonas?
Metronidazole
What is the treatment for infections caused by candida?
Clotrimazole
What are the risk factors for meningococcal disease?
Age: bimodal distribution, 3mnths to 3yrs.. 18yrs to 23 yrs.
Lack of bactericidal activity.
Travel to endemic states.
Splenectomy.
Complement deficiencies.
What are the virulence factors for N. Meningitidis
Nasal colonisation involving type 4 pilus.
Polysaccharide capsules that avoids host immunity.
Various secretion systems that helps to deliver toxins.
IgA protease that enhances survival within epithelial cells.
List the clinical features of N. Meningitidis
Acute meningitis, septicemia, purulent conjunctivitis, pericarditis.
Chronic septicemia with joint involvement (less common)
What are the microscopic observations for meningitidis diagnosis?
Gram negative intracellular Diplococci
The meningococcal serotype involved in local outbreaks is??
Serotype C
List the methods of infection control in meningitidis
Vaccination maybe offered.
Ciprofloxacin is recommended for all ages and in pregnant women.
Chemoprophylaxis is indicated for people who had close contact with the pt during the 7 days before illness.
Droplet infection control precautions are recommended.
What are the vacancies used in meningitidis?
Group c conjugate vaccine.
Group b protein vaccine.
Quadrivalent ACWY vaccine
