Negative Feedback Loop Flashcards
What occurs when blood pressure is low?
Kidneys determine blood pressure, a decrease will then cause renin to be released
Renin
An enzyme that causes angiotensin to be converted into angiotensin I, found in the kidneys
Angiotensin I
IThis is then converted to angiotensin 2 by ace found in the lungs
Angiotensin 2
Controls regulates aldosterone which then contributes to the retention of sodium and with water, hence creates an increased thirst, vasoconstrictions, and potassium excretion
Adh
Regulates fluid volume, antideuntic hormone that decreases urine output and hold onto water, stimulated when there is an increase in blood concentration,produced in the hypothalamus posterior pituitary
Hypovolemia
Dehydration
Deficit in fluid volume
from inadequate intake or excess excretion, decreased intro vascular and extracellular fluid volume which often triggers r-a-a-s to increase heartrate, constrict arteries and increase heart contractility
Hypervolemia
Excess increase of fluid in the extracellular compartment. Causing a retention in sodium and water, mean arterial blood pressure which inhibits antidieretic hormone and aldosterone, which should increase sodium ad water elimination.
Aldosterone
Produced in the rats negative feedback loop followed by angiotensin 2, it is meant to retain sodium and excrete potassium
Clinical manifestations of hypovolenia
Thirst, dry mucous membrane, weight loss, flattered neck veins, ‘ diminished skin turgor, long capillary refill >3 seconds, decreased urine output, increased heart rate, decreased blood pressure - a-l - C -
Water intoxication
Hypotonic hypovolemia, decreased sodium concentration, potential causes, diuretic therapy that inhibits antidiuretic hormone
Diuretic
Opposite of an antidiuretic hormone, instead makes you use the restroom, excretes sodium and water
Dehydration: treatments
Lactated ringers_intraveneous with isotonic solutions of normal saline
Treatments for water intoxication
Hypertonic saline solutions and loop diuretic to increase water elimination
RAAS system purpose
Meant to decrease urine output, increase sodium retention and via ADH hormone and Angiotensin 2
Complications of hypovolemia
Hypotension
Shock
Kidney injury
Tissue hypoxia