Necrotizing Periodontal Diseases Flashcards
Necrotizing Periodontal Diseases
Clinical Presentation
Sudden onset
and it can become a
“—”
Characterized by
(2)
chronic condition
gingival tissue
necrosis and
ulceration
Necrotizing Periodontal Diseases
A rare and destructive form of
periodontal disease caused by
microorganism in the context of
an impaired host response
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The 1989 Classification
stages (7)
Stage 1: Necrosis of the tip of interdental papillae
Stage 2: Necrosis of entire papillae
Stage 3: Necrosis extends to marginal gingiva
Stage 4: Necrosis extends to attached gingiva
Stage 5: Necrosis extends to labial/buccal mucosa
Stage 6: Necrosis and exposing alveolar bone
Stage 7: Necrosis perforates facial skin
The 2017 Classification
Forms of Periodontitis (3)
necrotizing gingivitis
necrotizing periodontistis
necrotizing stomatitis
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Epidemiology
Prevalence/Incidence
* —% in general populations
* —% in military personnel
* —% when it was close to the end of WW2
* —% in students
* —% in HIV/AIDS patients
0.5 - 3.3
0.2 - 6.2
4%-20.6
0.9 - 6.7
0 - 30
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0 - 30 % in HIV/AIDS patients
(3)
- Children (2.2‐5.0%)
- HIV adults (0.0–27.7% for NG and 0.3–9.0% for NP)
- HIV/AIDS patients (10.1–11.1% for NG and 0.3–9.0% for NP)
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Spirochetes and fusiform bacteria
(4)
P. intermedia
Treponema
Selenomonas
Fusobacterium species
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Specific features in HIV
(3)
Candida albicans
Herpes viruses
Superinfecting bacterial species
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Systemic modifying factors
PMN function
Pre-exsisting systemic disease
- Leukemia
- Leukopenia
- HIV/AIDS
Previous history of NPD
Pre‐existing gingivitis
Young age and ethnicity
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Environmental
Determinants
Mulnutrition
Stress
Insufficient sleep
Smoking/alcohol
consumption
Inadequate oral
hygiene
Stress/Anxiety/Depression
+ Negative Life Event
(3)
Increased Serum Cortisol
Immune System Depression
Necrotizing Gingivitis
- HIV:
- AIDS:
- Marked shift of — ratio
- normal ratio is –
Human Immunodeficiency Virus
Late stage of the HIV infection
CD4/CD8
2:1
AIDS: Late stage of the HIV infection
* Marked shift of
CD4/CD8 ratio
* normal ratio is 2:1
- AIDS: Late stage of the HIV infection
- Definition (one of the following)
(2)
- CD4 count <200 cells/mm3 in an HIV+ patient
- HIV+ patients with ≥ one opportunistic infection
- HIV+ patients with ≥ one opportunistic infection
(3)
- Pulmonary TB
- Recurrent pneumonia
- Invasive cervical carcinoma
HIV/AIDS
Disease severity based on CD4 counts (T-helper cell)
Normal count:
Preventive therapy:
Infection occur frequently
HIV+ becomes AIDS:
Significant changes occur:
900-1800
≤500
200-500
≤200
HIV/AIDS
Opportunistic infection CD4 count in blood
(cells/mm3)
Usually no signs of
immunosuppression-associated disease:
Staphylococcal skin infections,
candidiasis:
Herpes zoster, oral hairy leukoplakia:
TB, histoplasmosis, Kaposi’s sarcoma,
herpes simplex, etc:
Cytomegalovirus:
> 400-500
301-400
201-300
101-200
0-100
Viral count
Monitor status of disease,
guide therapy, prognosis
Absolute Neutrophil Count
Require antibiotic prophylaxis
when ANC<500
Platelet count
No procedures if below 50,000
(Normal 150,000-450,000)
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ANC calculation
WBC(in 1000s) X (% segmented [mature] + % bands [immature])
If the WBC is 4.3, with segmented % of 48%, and 2% bands, then the ANC is 4.3 x (.5)=2,150
HIV/AIDS
Oral lesions
(7)
- Candidiasis
- Viral lesions
- Major aphthous ulcers
- Necrotizing gingivitis
- Linear gingival erythema
- Necrotizing periodontitis
- Neoplasms
- Neoplasms
(3)
- Oral hairy leukoplakia
- Kaposi’s sarcoma
- Non-Hodgkins lymphoma
When to premeditate
HIV/AIDS patients for
invasive procedures?
A. When CD4 count is less than 200 cells/mm3
B. When platelet count is less than 50,000
C. When Absolute Neutrophil Count is less than 500
D. When the viral count is less than 500
C. When Absolute Neutrophil Count is less than 500
Light Microscopy
Necrotizing Gingivitis
It shows nonspecific acute inflammatory reaction
surrounding an ulcer within the stratified squamous
epithelium and the gingival connective tissue