NBME 11 Flashcards
Heat exhaustion
vs
heat stroke
exercise intolerance, increased core body temp, no neuro disturbances
hyperthermia + AMS + neuro deficits
hypernatremia, hyperchloremia, hyperkalemia
tx: remove individual from the heat, remove excess clothing, initiate cooling measures: immersion in cool water or evaporative cooling
rapidly progressive dementia and ataxia with stimulus indiuced or spontaneous myoclonas
Creutzfeldt Jakob disease
dx: CSF 14-4-4
autopsy: spongiform degeneration of the cortex
tx: death within one year, hospice, benzo for myoclonus
ethambutal ae
optic neuropathy : scotoma, red-green color blindness, blurred vision, partial visioin loss
neutropenia
thrombocytopenia
Isoniazid ae
inhibits synthesis of mycolic acids in cell walls
hepatoxic, neurotoxic, B6 pyridoxine deficiency (peripheral nueropathy and sideroblastic anemia)
Pyraxinamide ae
hepatoxic
hyper-uricemia
arthralgia
criteria for causation: (4)
- biologic plausibility
- dose-relationship
- specificity and strength of association
- temporal relationship
biological plausibility
observed association can be explained by a known biological pathway or mechanism
Specificy of the association
Strenght of the association
Specificy: one to one relationship between the exposure and the outcome
risk factor is the cause of ONE disease
Strenght: NEED R value (closer to 1 higher correlation)
Temporal relationship
if the exposure is known to precede the outcome
if pt were known to have no cardio dx prior to use of cigarettes then developed cardio dx
Dose-response relationship
the positive correlatino found between increased risk for cardiovasc dx and number of cigarettes smoked daily indicates that as the number of cig smoked daily, so does the risk for cardio vasc dz
number of cigs is dose
cardiovasc dz is response
hospital workers or high risk population PPD skin test:
greater than 10mm must treat
do xray
if active: quad tx
if latent: isoniazid for 9 months
pt with pneumonia, given abx, then preceded to have developed a parapneumonic effusion and then inot empyema (bacterial infection in pleural space)
next step
abx alone wont help, MUST PLACE CHEST TUBE
infusion of tissue plasminogen activator and recombinant deoxyribonuclease (DNAse) and iv abx into pleural space through chest tube
if chest tube fails –> video-assisted thorascopic surgery for decortication and drainage
children with hypertension
next step?
renal doppler ultrasound
serum renin and aldosterone
serum/urine metanephrines
on echo: pericardial effusion
collapse of right atrium at end of diastole
collapse of right ventricle in early part of diastole
cardiac tamponade
JVD hypotension, distant heart sounds
imapired right ventricular diastolic filling
risk factors any of: family hx of cvd, htn, dm, smoking
USPTF screening for men aged > 35 and women >45
lipid studies
tx: statins
anti-depressants with no sexual ae
mirtazapine : selective alpha 2 antagonist and serotonin modulator
Bupropion (dopamine and norepi)
ulcerative colitis managment meds
1) mesalamine enema , sulfasalazine
2) Corticosteroids: prednisone, Budesonide, hydrocortisone
3) anti-TNF (infliximab)
4) Janus Kinase enzyme inhibitor: Tofactinib
baby (less than 1yr) with recurrent UTI, voiding cystourethrography shows backflow of urine from bladder to renal pelvis
next step?
vesicoureteral reflux
can lead to pyelonephritis which later leads to renal scarring, htn, ckd
give: prophylactic daily antibiotc therapy
pelvic u/s: enlarged endometrial stripe
aub in post-menopausal
aub in premeno with prolonged exposure to estrogen
endometrial carcinoma
endometrial glands within the myometrium
large globular boggy diffusely enlarged uterus
transvag u/s : diffusely enlarged uterus, asymmetrical myometrial thickening, loss of endomyometrial border, subednometrial cysts
adenomyosis
tx: definitive: hysterectomy
conservative: progesterone IUD
gonadotropin-releasing hormone analogs
aromatase inhibitors
monoamniotic preg
vs
monochorionic preg
complications
conjoined twins or cord entaglement
twin twin trasnfusion or selective fetal growth restriction
hyperemesis gravidum management:
IV fluids
B6 supplements
antiemetics
usually seen in molar pregnancy so do a pelvic u/s and B-hcg levels
will see ketonuria or ketonemia
fever in pt with sickle cell and no spleen
any encapsulated pathogen: haemophilus influenza, neisseria meingitidis, streptococcus pneuomiae, pseudomonas, klebsiella
tx: ceftriaxone
friable ulcerative lesion on cervix painless bleeding
cervical cancer
uterine size out of proportion of expected gestational age
b hcg super high
u/x: diffuse echogenic structures within endometrial cavity along with ovarian theca lutein cysts
hydatidiform moles
third trimester painless vaginal bleeding, placental tissue partially or entirely over internal cervical os
placenta previa
gram positive bacillus, can cause bacterial meningitis in infants and elderly
tumbling motility
listeria
acute dystonic reactions: D2 antagonist
torticollis, retrocollis, opisthotonos 9arching back), oculogyric crisis (deviation of eyes)
haloperidol or fluphenazine
dopamine-cholinergic basal ganglia
tx: diphenydramine or benztropine (anticholinergics)
risk factors: male, young age, recent cocaine use, hx of acute dystonia
jaundice, hyperbilirubinemia, increased serum liver enzymes in pt with previous IV drug use
acute hepatitis
d/t viral (hep a, b, c), medications or supplements, autoimmune dz, ischemic injury
positive anti-HBc IgM means acute infection
anti-smooth muscle antibody found in autoimmune hepaititis: fatigue, wt loss, jaundice, n/v, pruritis, RUQ pain
refeeding syndrome
within 2 weeks of refeeding:
hypo-phoshpatemia hypo-kalemia, hypo-magnesmia
can lead to heart failure, resp failure, arrythmia, seizures
pt with celiacs has super high PTH but low vitamin-D and hypocalcemia and hypophosphatemia
celiacs –> malabsorption (intraepithelial lymphocytosis, villous atrophy, crypt hyperplasia) –> impaired vitamin D absorption –> hypocalcemia 2/2 osteomalacia
can also devlop secondary hyper-PTH with hypo-Ca and hypo-Phos
next step: DEXA : ASSESS bone density for pt with celiacs and at risk for osteomalacia
calcium absorption and bone mineral density imporve after starting gluten free diet
short digits (brachydactylyl), short stature, developmental delay, round facies
osteodystrophy – Albright hereditary osteodystrophy
pseudo-hypo-parathryoidism
impaired reposne of the kidney to parathyroid hormone –> hypocalcemia
Primary hyperparathyroidism
mcc
parathyroid adenoma (then hyperplasia, then carcinoma)
subperiosteal bone resporption, renal failure, hyper-ca, hypo-phos
painless jaundice and weight loss
pancreatic cancer
Marfans pt sports:
could do low-moderate intensity sports IF AND ONLY IF they do not have echo evidence: aortic root dilation, mod-to severe MR, or family hx of sudden cardiac death
NEVER allowed to do contact sports – risk for aortic dissection and rupture
annual echo and opthalmic exam in general for pt with marfans
UTI in age less than 1 yo
next step?
likely d/t congential urinary tract abnormality and might lead to ureteral obstruction and vesicoureteral reflux –> dilation of renal pelvis and calyces and compression/atrophy of renal parenchyma –> hydronephrosis
next step ** renal ultrasound**
and then fluoroscopic voiding cystourethrogram
vs IV pyelography: can show renal collecting duct, ureters, bladder –> but exposes child to radiation
muscle atonia lost –> violently acting out dreams, sometiems remember dreams + resting tremor
Parkinsons
dx: polysomnography showing lack of atonia during REM
tx: safe sleep enviroment, melatonin/clonazepam
(can also see this in lewy body dementia)
CSF: Leukocytes less than 100/mm3 with a predominance of lymphocytes (monocytes) normal or increased protein, normal glucose
aseptic (viral) meningitis
heart failure
cvp:
pcwp
svr:
SV:
CO:
cvp: high
pcwp: high
svr: high
SV: LOW DECREASED
co: low
impaired forward flow of blood – so body tried to maintain BP for peripheral perfusion by increasing SVR
pt with RA prior to srugery what should they get
lateral xray of cervical spine in flexion and extension for proper intubation – can lead to paralysis or death if translation instability is present
Vascular tumors
hemangioblastomas of retina and cerebellum
angiomatosis of the skin
can also see: renal clear cell carcinoma, pancreatic tumor, pheochromocytoma
VHL
do CT SCAN OF ABDOMEN for kindey, pancreas, adrenals
tx: surgical excision
bloody diarrhea, thrombocytopenia, hemolytic anemia
E coli (shiga toxin producing)
shiga toxin –> leads to microvascular thrombosis –> platelet consumption and shearing –> form schistocytes
elevated LDH
thrombosis in renal vasculature –> endothelial damage –> renal injury
HUS (hemolytic uremic syndrome) renal failure, thrombocytopenia, microangiopathic hemolytic anemia
pt with fever but bradycardia
bacteremia, rose colored spots on chest and abdomen
salmonella typhi
no spleen
what vaccines?
meningococcal conjgate (against serotype B) must be given every 5 years
pneumococcal PCV13 PPSV23
annual influenza
Haemophilus influenza type B
mechanical ventilation after 10-14 days
next step?
tracheostomy tube – decreased risk for laryngeal injury, better comfort, easier ventilator weaning
complications: tracheal stenosis or tracheomalacia
tracheoarterial fistula
site infection
fever, productive cough, and pulmonary infiltrate
dx
tx
Community acquired pneumonia
Strep Pneumo, haemop influ, moraxella, mycoplasma pneumo, staph aureus, chlamydophilia pneumo
tx: azithromycin, doxycylcine, amoxicillin
if have comorbidities: COPD, DM, liver, cardiac, renal dx
amoxicillin-clav or levoloxacin
expect to get better within 24 to 48 hrs
no need for repeat imaging
14M with consistently decreased growth velocity (always 3rd percentile), bone age younger than chronological age, tanner stage 1
Constitutional growth delay
pre-puberty but once puberty hits sudden spike in height
short parents, normal gain of height velocity, bone age corresponds to chronological age
Familial hereditary short stature
vs constitutional will not see that normal gain of height velocity and bone age is younger