Natural Products (anti-cancer)

Question 1

Inhibits tubulin polymerization?

Enhance tubulin polymerization & prevent depolymerization ?

Answer 1

Inhibits tubulin polymerization? Vinca alkaloids

Engave tubulun polymerization & prevent depolymerization ? Taxanes

Question 2

inhibit the process of tubulin polymerization,
which disrupts assembly of microtubules?

A) taxanes
B) epidophyllotoxins
C) vinca alkaloids

Answer 2

C) vinca alkaloids

Vincristine
Vinblastine
Viorelbine

Question 3

All vinca alkaloids are cell cycle specific

They inhibits mitosis acting on …

A) S phase
B) M phase
C) G phase

Answer 3

B) M phase

Question 4

Vincristine

C. CNS = neurotoxicity for both autonomic and peripheral neuropathy

Cisplatin (platinum compounds) is only periheral neurotoxicity

Question 5

Vinblastine

B. Bone marrow suppression (myelosuppression)

Question 6

Vinorelbine

Myelosuppression with neutropenia

Question 7

Taxanes

Paclitaxel. Hyperseinsitivity
Docetaxel
Cabazitaxel
Ixabepilone
Eribulin. Block G2-M phase

Question 8

Hypersensitivity reactions may be observed

reduced by premedication with dexamethasone, and diphenhydramine.

Answer 8

Paclitaxel

Question 9

An albumin-bound paclitaxel nanoparticle formulation (nab-paclitaxel or Abraxane) is
not associated with HSRs

Question 10

Nab-paclitaxel is indicated for pancreatic cancers.

Same as folfox (oxaliplatin)

Question 11

poor substrate for the multidrug resistance
P-glycoprotein efflux pump and may, therefore, be useful for treating multidrug-resistant
tumors

A) Docetaxel
B) Cabazitaxel
C) Ixabepilone
D) Eribulin

Answer 11

B) Cabazitaxel

Question 12

binds directly to βtubulin subunits on microtubules, leading to inhibition
of normal microtubule dynamics.

A) Docetaxel
B) Cabazitaxel
C) Ixabepilone
D) Eribulin

Answer 12

C) Ixabepilone

Question 13

Oral bioavailability is about 50%, requiring oral dosage to be twice that of IV dosage.

 Up to 30–50% of an administered dose of drug is excreted in the urine

Answer 13

Etoposide

Question 14

forms a complex with topoisomerase II, the enzyme responsible for cutting
and religating double stranded DNA

Answer 14

Etoposide

Question 15

G2-S phase
cell cycle specific

A) eribuln
B) camptothecin
C)bleomycin
D) etoposide

Answer 15

D) etoposide. (G2-S)

A) eribuln. (G2-M)
B) camptothecin (G2-M)
C)bleomycin (G2-M)

Question 16

inhibit the activity of topoisomerase I (topo
I), the key enzyme responsible for cutting and re-ligating single DNA strands.

They are G2-M phase cell cycle specific.

A) eribuln
B) camptothecin
C)bleomycin
D) etoposide

Answer 16

Topo 1 and G2-M

B) camptothecin

Question 17

prodrug that is converted mainly in the liver by the carboxylesterase
enzyme to govitecan, the SN-38 metabolite that is 1000-fold more potent as an
inhibitor of topo I than the parent compound

Hint: “can” family.
A) irinotecan
B) topotecan
C) deruxtecan

Answer 17

A) irinotecan

Question 18

conjugated with trastuzumab to form an antibody drug conjugate (ADC).

The activity of this molecule is dependent on HER expression and not on HER2 gene
amplification

Hint: “can” family.
A) irinotecan
B) topotecan
C) deruxtecan (the most potent)

Answer 18

C) deruxtecan ( the most potent)

Question 19

Myelosuppression and diarrhea (early and late) are adverse events.
Early diarrhea treated with atropine
Late diarrhea leads to electrolyte imbalance & dehydration

Hint: “can” family.

A) irinotecan
B) topotecan
C) deruxtecan (the most potent)

Answer 19

A) irinotecan

Question 20

Anthraxycline is given?

IM
IV
Topical
Oral

Answer 20

IV

Question 21

Anthracycline is cell cycle specific?

Answer 21

Nooooo its CCNS

NON-SPECIFIC

Question 22

Anthracyclines S.E?

Q. Radiation recall reaction ? Anthracycline

Myelosuppression

Cardiotoxicity

Answer 22

Rubin
Mitoxantrone

Doxorubicin
Daunorubicin
Idarubicin
Epirubicin
Mitoxantrone

Question 23

A blue discoloration of the fingernails, sclera, and urine is observed 1–2 days after drug
administration.

S.E of drug?
Hint: Anthracycline family

So rubin or Mitoxantrone

A) Doxorubicin
B) Daunorubicin
C) Idarubicin
D) Mitoxantrone

Answer 23

D) Mitoxantrone

Question 24

Dilated cardiomyopathy, HF

Drug xx —> approved to prevent
or reduce anthracycline-induced cardiotoxicity in women with metastatic breast
cancer

A) dexamethasone
B )Diphenhydramine
C) dextrazoxane

Answer 24

C) dextrazoxane

Dexamethasone & Diphenhydramine for hypersensitivity reaction of paclitaxel

Question 25

This agent is active in all phases of the cell cycles Bleomycin or mitomycin c?

Answer 25

Mitomycin c (CCNC) Bleomycin ( G2-M phase)

Question 26

There is systemic toxicity when mitomycin is administered via the intravesical route. (True/ false)

Answer 26

Falseeee The is no systemic toxicity when given IV mitomycin c

Question 27

Pulmonary toxicity is dose-limiting for.. A) paclitaxel B) dixorubicin C) bleomycin

Answer 27

C) bleomycin

Question 28

Pulmonary toxicity is dose-limiting for bleomycin and usually presents as pneumonitis with cough fibrosis dyspnea dry inspiratory crackles on physical examination