Anti-cancer Flashcards
(15 cards)
4hydroxycyclophosphamide <—> aldophosphamide
Occur for drug called?
Enzyme?
Cyclophosphamide
Cyp450
aldophosphamide results cyclotoxic forms via non-enzymatic cleavage and are?
Phospharamide
Acrolein
Hemorrhagic cyctitis caused by?
Which then cause hematuria
Acrolein
In addition to Alkylation
It involves carbomylation of lysine into isocyanates
N7 and O6 of guanine leads to G-C crosslink
A)bitrogen mustard
B) Nitrosoureas
B) Nitrosoureas.
Carmustine
Lomustine
Semustine
Tratment of brain tumor?
Nitrosoureas
It inhibits DNA, RNA, protein biosynthesis —>
prolong interphase & produces chromosome
breaks
A) procarbazine
B) dacarbaxine
C) bendamustine
A) procarbazine
One metabolite is a weak monoamine oxidase inhibitor (MAOI), & adverse event can
occur when xxxx is given with other MAOI
A) procarbazine
B) dacarbaxine
C) bendamustine
A) procarbazine
Methylates DNA and inhibits DNA synthesis
inhibits DNA synthesis by generating (( methyl
carbonium ion ))
A) procarbazine
B) dacarbaxine
C) bendamustine
B) dacarbaxine
- Form DNA crosslinks — > Inhibit DNA synthesis
- Inhibit mitotic checkpoints & induces mitotic
catastrophe
Catastrophe & checkpoint = benda..
A) procarbazine
B) dacarbaxine
C) bendamustine
C) bendamustine
Form intrastrand and interstrand crosslinks in
the DNA at N7 of guanine, N3 of adenine, and
O6 of cytosine
In addition to targeting DNA, bind to both cytoplasmic and nuclear proteins
Platinum compounds
Cisplatin
Carboplatin
Oxaliplatin
S.E: neurotoxicity (not reversible)
Associated with peripheral sensory neuropathy
Occur even at small doeses
Cisplatin
its main dose-limiting toxicity is myelosuppression
Less renal, GI toxicity
Used for refractory hematologic malignancies before transplantation
Carboplatin
tumors that are resistant to cisplatin or carboplatin on the basis of
mismatch repair defects are not cross-resistant to oxaliplatin
Used in combination with 5-FU and leucovorin, termed folfox regimen for CRC
A) Cisplatin
B) Carboplatin
C) Oxaliplatin
C) Oxaliplatin
Neurotoxicity
Acute… worsened by cold
Chronic.. dose-dependent on cumulative does and ( reversible )
A) Cisplatin
B) Carboplatin
C) Oxaliplatin
C) Oxaliplatin
