Anti-viral Flashcards by Ali Atash

Q

(-)Thymidine kinase
(-) DNA polymerase —> chain termination

A) Valacyclovir
B) Penciclover
C) Docosanol
D) Acyclovir

A

D) Acyclovir

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Q

Toxicity
Gi distress and headache
Does not cause myelosuppression

A) Valacyclovir
B) Penciclover
C) Docosanol
D) Acyclovir

A

D) acyclovir

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Q

It is myelosupressive drug?

A) Valacyclovir
B) Ganciclovir
C) Docosanol
D) Acyclovir

A

B) Ganciclovir

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Q

Does not cause chain termination?

A) Valacyclovir
B) Penciclover
C) Docosanol
D) Famciclovir

A

B) Penciclover

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Q

Prodrug converted to penciclovir?

A) Valacyclovir
B) Penciclover
C) Docosanol
D) Famciclovir

A

D) Famciclovir

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Q

Prodrug converted to acyclovir?

A) Valacyclovir
B) Penciclover
C) Docosanol
D) Famciclovir

A

A) Valacyclovir

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Q

Which drug reaches plasma levels 3-5 times greater than acyclovir?

A) Valacyclovir
B) Penciclover
C) Docosanol
D) Famciclovir

A

A) Valacyclovir

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Q

Aliphatic alcohol
Prevent viral entry & replication
Inhibit fusion of HSV envelope and plasma membrane

A) Valacyclovir
B) Penciclover
C) Docosanol
D) Famciclovir

A

D) Docosanol

Ooool (alcohol)

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Q

Phosphorylated by UL97 ?

A) Ganciclovir
B) acyclovir
C) cidofovir
D) Letermovir
E) Foscarnet

A

A) Ganciclovir

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Q

Ganciclovir cause severe neutropenia with?

A

Zidovudine

Gan + Vido = severe neutropenia

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Q

Cytosine analog
Activated by host cell kinase?

A) Ganciclovir
B) acyclovir
C) cidofovir
D) Letermovir
E) Foscarnet

A

C drug = cytosine

C) cidofovir

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Q

Does not require phosphorylation via viral kinase for antiviral activity?

A) Ganciclovir
B) acyclovir
C) cidofovir
D) Letermovir
E) Foscarnet

A

C) cido(F)ovir

E) (F)oscarnet

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Q

Inhibits RNA,DNA Polymerase, Reverse transcriptase (HIV)?

A) Ganciclovir
B) acyclovir
C) cidofovir
D) Letermovir
E) Foscarnet

A

E) Foscarnet

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Q

A drug Highly specific to CMV?

A) Ganciclovir
B) acyclovir
C) Foscarnet
D) cidofovir
E) Letermovir

A

E) Letermovir

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Q

This drug is highly specific to CMV
The most effective against CMV
It inhibits terminase complex required for DNA packing and processing

A) Ganciclovir
B) acyclovir
C) Foscarnet
D) cidofovir
E) Letermovir

A

E) Letermovir

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Q

Inti-influenza drugs

Oseltamivir & zanamivir
Baloxavir
Amantadine & Rimantadine

A

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Q

Inhibitor of neuraminidase?

Oseltamivir
Baloxavir
Amantadine
Zanamivir
Two answers

A

Two answers: Oseltamivir & zanamivir

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Q

Oseltamivir.

Zanamivir.

Route of administration?

A

Oseltamivir. O means orally

Zanamivir. Intranasal

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Q

This drug cause neuropsychiatric and GI symptoms?

A) Zanamivir
B) Baloxavir
C) Amantadine
D) Oseltamivir

A

D) Oseltamivir

Q

This drug has a toxicity of cough + throat discomfort?

A) Zanamivir
B) Baloxavir
C) Amantadine
D) Oseltamivir

A

A) Zanamivir

Remember

Neuropsychiatric = oseltamivir
Cough + throat discomfort = zanamivir

Q

Has long half life of 80 hours?
+Interfere with RNA transcription

A) Zanamivir
B) Baloxavir
C) Amantadine
D) Oseltamivir

A

B) Baloxavir

Q

Prevent uncoating by binding to protein channel?

A) Zanamivir
B) Baloxavir
C) Amantadine
D) Oseltamivir
E) Rimantadine
F) Amantadine & Rimantadine

A

F) Amantadine & Rimantadine

Q

Drug x activity is no greater than that of amantadine, but it has a longer half-
life and requires no dosage adjustment in renal failure.

A) Zanamivir
B) Baloxavir
C) Amantadine
D) Oseltamivir
E) Rimantadine
F) Amantadine & Rimantadine

A

E) Rimantadine

Q

A

Drugs used in HBV?

INF- alpha Adefovir Entecavir Lamivudine Ribavirin

Increase the activity of Janus Kinase (JAKs) This enzyme phosphorylate (STATs) to increase the formation of antiviral proteins?

Interferon- alpha

Activation of ribonulease that degrades viral mRNA Drug x called?

Interferon-alpha

Drug X promotes formation of natural killer cells.. that desroys infected liver cells?

Interferon-alpha

Conventional INF-ALPHA administered daily or 4 times a week Polygaged (PEG) form of INF-alpha administered? Twice a week? Once a week?

Once a week

Toxicity of INF-alpha is ? كآبة و عقل مرتبك

Mental confusion + depression

This drug is unaffected by food and has good oral bioavailability ? A) INF-alpha B) Entecavir C) Adefovir dipivoxil

C) Adefovir dipivoxil

Polygared INF-alpha with …. For chronic HCV ربا

Ribavirin

Lactic acidosis and hepatomegaly with steatosis occur in drug? A) INF-alpha B) Entecavir C) Adefovir dipivoxil

C) Adefovir dipivoxil

Entecavir MAO? inhibits HBV DNA polymerase? inhibits HDV DNA polymerase? inhibits HCV DNA polymerase?

inhibits HBV DNA polymerase?

Inhibitor of Reverse transcriptase (HIV) لمياء A) Lamivudine B) Entecavir C) Adefovir dipivoxil

A) Lamivudine

Drug x has a longer intracellular half-life in HBV-infected cells than in HIV-infected cells?

Lamivudine

Precise mechanism .. unknown Prevent capping of viral mRNA? + Inhibits guanosine triphosphate ربا A) Lamivudine B) Entecavir C) Ribavirin

C) Ribavirin

NS5A “asvir” Act on ER (endoplasmic reticulum)

NS5B “Buvir” Polymerase inhibitor

Dasabuvir NS5B “Buvir” Nucleoside or non-nucleoside?

non-nucleoside analog Allosteric inhibitor

SofosBuvir is NS5B? Allosteric inhibitor of NS5B ? Target catalytic site of NS5B?

Allosteric inhibitor of NS5B ? Noooo its DasaBuvir Target catalytic site of NS5B? Yes, sofosBuvir

Protease inhibitorv A) NS5A B) NS5B C) NS3/4A

C) NS3/4A

inhibitors of the NS3/4A serine protease

Grazoprevir, Voxilaprevir NS3/4A “previr”

X… is a potent, protease inhibitor, reversibly binding to HCV NS3/4A protease. Grazoprevir or Voxilaprevir

Grazoprevir or Voxilaprevir

only available in combination with elbasvir (NS5A)?

“Previr” (Grazoprevir, Voxilaprevir)