Nasal Diseases Flashcards

1
Q

Approaching nasal disease.

A

Hx.
PE.
Problem list and differentials.
Diagnostic investigations.
Interventions/management.

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2
Q

Predispositions and signalment considerations.
Other Hx considerations.

A

Age.
Breed:
- brachycephalic and dolichocephalic.
- working/outdoor (FBs).
Onset of clinical signs:
- Acute v progressive.
Trauma?
Any difficulty eating/eating on one side (dental disease)?
Vomiting/regurgitation?

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3
Q

Nasal disease clinical signs.

A

Nasal discharge:
- unilateral v bilateral.
- appearance: serous, mucopurulent, haemorrhagic.
- any change over time?
Sneezing.
Reverse sneezing.
Stertor / stridor.
Systemic signs.
CNS signs.

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4
Q

PE.

A

Listen for noises.
Nasal discharges - types?
Facial deformity.
Pain.
Nasal planum depigmentation.
Crustiness etc.
Assess airflow bilaterally.
- glass slide (clouding).
Assess regional LNs.
Retropulsion of the eyeballs / exophthalmia.
Dental disease?
Ophthalmic disease?

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5
Q
  1. Inflammatory differentials for nasal disease.
  2. Infectious differentials for nasal disease.
A
  1. Idiopathic.
    Allergic.
    Irritation.
  2. Bacterial: secondary.
    Virus:
    - Herpesvirus and calicivirus in cats.
    - CDV.
    Fungal:
    - Aspergillus in dogs mainly.
    - Cryptococcus in cats mainly.
    Parasitic:
    - Pneumonyssus caninum in dogs.
    - cutebra sp.
    Trauma/fracture.
    FB.
    Systemic causes (epistaxis):
    - coagulopathy.
    - hyperviscosity syndrome.
    - systemic hypertension.
    Dental disease and oronasal fistula.
    Nasopharyngeal polyp in cats.
    Nasopharyngeal stenosis.
    GI reflux w/ anaesthesia.
    Brachycephalic syndrome.
    Ciliary dyskinesia.
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6
Q
  1. Diseases of unilateral presentation.
  2. Diseases of bilateral presentation.
A
  1. FB, nasal tumour (early course, older patient), aspergillus (early course, younger dogs, nasal depigmentation, dolichocephalic, epistaxis), chronic rhinitis (Dx of exclusion).
  2. Chronic rhinitis (idiopathic), URT viruses (vac, ocular signs, previous signs), aspergillus (advanced), nasal tumour (advanced, absent to reduced nasal air flow, CNS signs).
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7
Q

Presentation of chronic rhinosinusitis in cats.

A

Idiopathic.
Unclear role of bacterial and viral infections.
>1mth of clinical signs.
- sneezing and nasal discharge.
- increased URT noises.
- usually bilateral but can be unilateral.
- often preserved nasal airflow:
– if unilateral and no nasal airflow, then tumour and fungal rhinitis higher on the list.

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8
Q

Presentation of dogs w/ chronic rhinitis?

A

Underlying allergic, irritant, immune-mediated process?
Whippets and dachshunds predisposed.
Chronic, gradually progressive disease:
- sneezing, snorting and mucoid/mucopurulent nasal discharge.
- most commonly bilateral but can be unilateral.
- poss. airway obstruction.
- poss. post-nasal drip causing coughing.
- facial pain/deformity not expected.

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9
Q

Presentation of nasal FBs.

A

Usually compatible Hx.
Acute onset of clinical signs in a previously well patient.
Sneezing, gagging and pawing at the face.
Progression to purulent nasal discharge and foul smelling.

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10
Q

Sino-nasal aspergillosis presentation.

A

Predisposition:
- Meso/dolichocephalic dog breeds.
– Aspergills fumigatus.
- Brachycephalic cats: sino-orbital.
– Aspergillus felis.
Clinical signs:
- mucopurulent nasal discharge or epistaxis.
- unilateral or bilateral.
- sneezing, nasal pain (head-shy), nasal depigmentation.
- uncommonly: stertor, facial deformity, CNS signs.

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11
Q

Nasal neoplasia presentation.

A

Usually older patients.
Chronic history of nasal discharge (often mucopurulent to haemorrhagic).
Sneezing.
Dyspnoea.
Reduced airflow.
Stertor.
Facial distortion.
Pain.
Ocular discharge/exophthalmia.

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12
Q

Diagnostic investigation options for patient presenting w/ nasal disease.

A

Blood tests.
Swabs.
Diagnostic imaging.
Rhinoscopy.

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13
Q

Blood tests.

A

Tests for bleeding disorders:
- platelet count.
- PT/APTT.
Serology for fungal disease:
- Aspergillosis in dogs – often unhelpful.
- Cryptococcus in cats – good sensitivity and specificity.
Viral testing in cats:
- PCR for FHV/FCV for acute disease.
- ELISA FIV (Ab) / FeLV (Ag) for chronic disease.

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14
Q

Nasal investigations under GA.

A

Full oral exam:
- use bitch spay hook to lift soft palate e.g. glass blade.
- otoscope for visualisation.
- forceps.
Dental probing.

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15
Q

Nasal diagnostic imaging.

A

X-rays:
- intra-oral nasal views most helpful.
- consider dental x-ray plates.
- consider thoracic radiographs - mets.
Radiographic signs to look for:
- FBs e.g. metallic.
- Tooth root abscesses/dental disease.
- Turbinate destruction.
- Nasal bone invasion.
- Increased soft tissue opacity.
- Check sinuses – frontal sinuses.
Head CT for better details.

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16
Q

Nasal sampling under GA.

A

Nasopharyngeal swab in cats.
Forced nasal flushes:
- Dx and Tx for FBs.
- Pack pharynx appropriately.
Nasal biopsy:
- Blind or endoscopic.
- Careful w/ landmarks.
- Check coagulation times.
- Histopathology and culture.
– neoplasia.
– aspergillosis.

17
Q

Rhinoscopy.

A

Referral?
Rigid rhinoscope in some first opinion practices.
Flexible anterograde rhinoscopy likely referral procedure. Retrograde view of nasopharynx.
See fungal plaques and lots of mucus w/ aspergillosis.
Could help w/ identifying and removing some FBs.

18
Q

What to expect post biopsy/rhinoscopy.

A

Bleed +++
- ice packs on nose.
- intranasal adrenaline.
Some patients may breathe better if severe nasal congestion.

19
Q

Dx of chronic rhinosinusitis in cats by exclusion.

A

FHV/FCV PCRs - often negative, though some carriers.
Imaging - increased soft tissue density +/- turbinate lysis.
Rhinoscopy - mucus +/- turbinate destruction.
Histopathology - usually mixed inflammation, fibrosis, necrosis, glandular hyperplasia.

20
Q

Tx chronic rhinosinusitis in cats.

A

Supportive:
- Steam/nebulise 10-15mins BID - useful.
- Mucolytics: Bromhexine.
- Saline drops (if tolerated).
- Encourage to eat, nursing care, ensure can smell.
NSAIDs: meloxicam.
Doxycycline 6w course - ideally sample first.
Antivirals: famciclovir for FHV.
Antihistamines (if allergy associated).
Glucocorticoids:
- if NSAIDs do not work and no bacterial/viral component.
- Do NOT give concurrently w/ NSAIDs!

21
Q

Dx of chronic rhinitis in dogs by exclusion.

A

Radiographic changes usually mild and non-specific.
CT can be normal or show mild to moderate bilateral or unilateral turbinate destruction.
Rhinoscopy:
- mucus accumulation requires flushing +++.
- hyperaemic mucosa.
Histopathology: lymphoplasmacytic inflammation.

22
Q

Tx for chronic rhinitis in dogs.

A

Minimise irritants/allergens.
ABX?
- bacterial rare in dogs, empiric Tx rarely justified.
- doxycycline can be considered – 1-2w, extend to 4-6w if good response.
NSAIDs: meloxicam.
Glucocorticoids - taper to anti-inflammatory dose and consider inhaled.
(Not to be given w/ NSAIDs).
Humidification/nebulisation.
Antihistamine.
Hypoallergenic diet.
Azithromycin - AB w/ immunomodulatory properties.

23
Q

Nasal neoplasia.

A

Radiotherapy: usually best Tx.
- except chemotherapy for lymphoma.
Sx unrewarding.
Supportive Tx: NSAIDs COX-2 (meloxicam).
- analgesia.
- inhibition of tumour growth.

24
Q
  1. Aspergillosis on cytology.
  2. Aspergillosis on histopathology.
  3. Aspergillosis on fungal culture.
  4. Aspergillosis on ELISA or gel immunodiffusion Ab serology.
  5. Aspergillosis PCR.
A
  1. Usually mixed inflammation and fungal hyphae.
    Care w/ contaminant.
    Rarely useful.
  2. Endoscope-guided.
    Mixed inflammation and fungal hyphae and bone destruction.
  3. Endoscope biopsies.
    3+ days for results.
  4. Negative - cannot rule out – moderate sensitivity.
    Positive - very reliable - excellent specificity.
  5. not useful.
25
Q

Aspergillosis Tx.

A

Debride endoscopically.
- may require trephination to access frontal sinuses.
Topical antifungal (clotrimazole):
- questionable use if not intact cribriform plate.
Non-invasive catheter soaks w/ clotrimazole:
- foley catheters in nasopharynx and rostral nasal cavity.
- restricts drug to nasal cavity.
- success increases w/ subsequent treatments.
Trephination:
- flush w/ saline then clotrimazole.
- installation of clotrimazole cream.
- Successful treatment but often required to repeat.