naloxone narcan

Question 1

drug classification

Answer 1

opiate antagonist/ antidote

Question 2

mechanism of action

Answer 2

competetive opiate R antagonist- displaces narcotic molecules, has greater affinity for R site, but shorter duration

Question 3

onset

Answer 3

less than 2 min IV, 2-10 min IM/ET

Question 4

peak

Answer 4

less than 2 min IV, 2-10 min IM/ET

Question 5

duration

Answer 5

20-120 min

Question 6

half life

Answer 6

60-90min

Question 7

indications, field use

Answer 7

partial/complete reversal of respiratory depression caused by narcotic/opiate
coma of unknown origin
R/O narcotic involvement in polypharmacy overdose prior to RSI

Question 8

contraindications

Answer 8

hypersensitivity

Question 9

side effects, adverse reactions

Answer 9

hypotension, hypertension, ventricular dysrhythmias, n+v, seizures

Question 10

Dose adult

Answer 10

0.4-2mg slow Iv push, q 2-3 min IV,IO or until respiratory status improves
2mg IM
1 mg per nare IN, ET or until respiratory status improves

Question 11

dose pedi

Answer 11

0.1mg/kg IM,IV,IN max dose of 2mg/dose

Question 12

precautions

Answer 12

caution with pt potentially dependend on narcotics, may induce withdrawal, including newborn infants with addicted mothers

Question 13

Drug on Drug interactions

Answer 13

may induce withdrawal on narcotic dependend pt