haloperidol haldol

Question 1

drug classification

Answer 1

butyrophenone antipsychotic, neuroleptic

Question 2

mechanism of action

Answer 2

mesolimbic D1/D2 antagonist- depresses release of hypothalamic and hyophyseal hormones, depresses the recticular activating system, thus affecting basal metabolism, body temp, wakefulness, vasomotor tone and emesis

Question 3

onset

Answer 3

30-45 min

Question 4

peak

Answer 4

10-20min

Question 5

duration

Answer 5

varies

Question 6

half life

Answer 6

3-35 h

Question 7

indications, field use

Answer 7

acute psychotic episode

Question 8

contraindications

Answer 8

CNS depression

agitation secondary to shock or hypoxia

Question 9

side effects, adverse reactions

Answer 9

EPS, insomnia, restlessness. drowsiness, seizures, dry mouth, constipation, respiratory depression, tachycardia, hypotension, prolonged QT syndrome, torsades

Question 10

dose adult

Answer 10

5 mg IM, q 4-8h PRN

Question 11

pedi dose

Answer 11

1-3 mg IM, q 4-8 h PRN, max of 0.15mg/kg/day

Question 12

precautions

Answer 12

may impair physical and mental abilities, may cause orthostatic hypotension, may cause EPS and dystonic reactions

Question 13

drug on drug interactions

Answer 13

caution in patients taking lithium may cause encephalopathic syndrome- irreversible brain damage-
may increase change of hypotension when taken with antihypertensives
additive effects with depressants and other anti-psychotics- increased CNS depression