lorazepam ativan

Question 1

drug classification

Answer 1

anticonvulsive, sedative, hypnotic, benzodiazepine

Question 2

mechanism of action

Answer 2

positive allosteric modulator for GABAa receptors- binds to benzo receptor side on chloride channels and potentiates the binding and effects of GABA -increases intracellular CL-concentration leading to hyperpolarization of the cell

Question 3

onset

Answer 3

1-5 min IV, 15-30 min IM

Question 4

peak

Answer 4

15-20 min IV, 2h IM

Question 5

duration

Answer 5

6-8 h

Question 6

half life

Answer 6

10-20 h

Question 7

indications, field use

Answer 7

major motor seizures
pre med for cardioversion on TPA
acute anxiety
alcohol withdrawal/ dilirium tremens
post intubation sedation

Question 8

contraindications

Answer 8

hypersensitivity

Question 9

side effects, adverse reactions

Answer 9

hypotension, drowsiness, amnesia, respiratory depression, blurred vision, altered mental status, n+v

Question 10

dose adult

Answer 10

seizure 4 mg IV, IO
pre medication , anxiety, withdrawal 0.5mg-2mg slow IV, IO / 1-4 mg IM
Post intubation 2-4 mg slow IV, IO q 5-10 minutes

Question 11

pedi dose

Answer 11

0.05mg/kg slow IV/IO

Question 12

precautions

Answer 12

may cause CNS and respiratory depression

caution with acute alcohol intoxication

Question 13

drug on drug interactions

Answer 13

additive effects with CNS depressants and alcohol