NALOXONE Flashcards
CLASS
OPIATE ANTAGONIST/ ANTIDOTE
NALOXONE
NARCAN
MOA
COMPETITIVE OPIATE R ANTAGONIST DISPLACES NARCOTIC MOLECULES HAS GREATER AFFINITY FOR R SITE BUT SHORTER DURATION.
PHARMACOKENETICS
ONSET OF ACTIN <2 MINUETS IV, 2-10 MINUTES IM/IN
DURATION OF EFFECT 20-120 MINUTES
HALF-LIFE- 60-90 M
INDICATIONS FIELD USE
PARTIAL/COMPLETE REVERSAL OF RESPIRATORY DEPRESSION CAUSED BY OPIATES
COMA OF UNKNOWN ORGIN R/O OPIATE INVOLVMENT IN POYPHARM OVERDOSE PRIOR TO RSI
CONTRAINTICATIONS
HYPERSENSITIVITY
SIDE EFFECTS ADVERSE REACTIONS
HYPOTENSION HYPERTENSION VENTRICULAR DYSRYTHMIAS NV SEIZURES
DOSE
ADULT- 0.4-2MG IV IO IM
IN-1MG X 2 NARES
PEDI- 0.1 MG/KG IM MAX 2MG/DOSE
PRECAUTIONS
DEPENDENT PT MAY PUT THEM INTO WITHDRAWAL INCLUDES NEWBORNS INFANTS
DRUG DRUG
WITHDRAWAL TO OPIATE