NAGE Flashcards
1
Q
What does TFIID contain?
A
TATA binding protein and TBP accessory factors
2
Q
What does binding of TFIID do?
A
Unwinds DNA to make minor groove larger and unwinds in one direction so transcription is unidirectional
3
Q
What does TFIIH promote?
A
Increases unwinding of DNA
4
Q
What factor determine the express of transcription factors?
A
Cell lineage
Signals outside cell
Mutated TFs
5
Q
How does the 5 prime cap form?
A
Terminating phosphate is hydrolysed with diphosphate
React with alpha phosphate from GTP
methylated
= 7methylguanylate cap
6
Q
What are the symptoms of thalassaemia?
A
Hepatic fibrosis
Cardiomyopathy
Darkening skin
7
Q
What are the symptoms of polio?
A
Vomiting Pain in neck Fatigue Fever Headache
