N365 Exam 3 Flashcards
Mucolytic; breaks up mucus & makes it more soluble
ADRs: Fever, some N/V, Stomatitis, Rhinorrhea
Bronchospasm in asthmatics
Rotten egg odor; wash face after use
ANTIDOTE FOR ACETAMINOPHEN OVERDOSE
Acetylcysteine (Mucomyst)
Expectorant, bronchomucotropic; increases volume but decreases viscosity of mucus
ADRs: Rare. Occasional GI irritation
HYDRATION is very important
Guaifenesin (Robitussin, Mucinex)
Sympathomimetic (non-selective); BRONCHODILATOR; vasoconstriction to dec. mucosal edema, stimulates HR and force of contraction, bronchial smooth muscle relaxation
ADR: Nervousness, insomnia, FEAR, tremors, TACHYCARDIA, headache, dyspnea
Use caution with CAD, HTN, and hyperthyroid
USE WITH MAOIs = SEVERE HTN
Epinephrine (Adrenalin)
Sympathomimetic (non-selective beta stimulant); BRONCHODILATOR; b1 & b2 stim.
ADRs: tachycardia, palpitation, headache, nausea, tremor, insomnia; MORE USED, LESS EFFECTIVE
MOST POWERFUL BRONCHODILATOR
Isoproterenol (Isuprel)
Sympathomimetic; BRONCHODILATOR (selective B2 stimulant)
Relaxation of bronchial smooth muscles (some B1 action at high doses)
ADR: Few; peripheral dilation = dec. BP & tachycardia; Tremors, nervousness, palpitations, N/V, lethargy, tinnitus
SABA = rescue inhaler
Use caution with diabetes, HTN, cardiac arrhythmias
Albuterol (Proventil, Ventolin)
Anticholinergic BRONCHODILATOR, Short-acting muscarinic antagonist (SAMA); blocks cholinergic receptors to dec. bronchial tone
ADRs: Few. Dry mouth, pharyngeal irritation
Combivent and Spiriva in same class
Ipratropium (Atrovent)
BRONCHODILATOR, Methylated Xanthine; relaxes bronchial smooth muscle, stim. heart, CNS, & medullary resp. center
ACTS LIKE CAFFEINE
ADRs: GI (anorexia, N/V, abd. discomfort); CNS (insomnia, irritability, SEVERE CONVULSIONS); CV (tachycardia, severe hypotension, arrhythmias); Renal (urinary freq.)
Dec. 1/2 life in smokers; Take with food
THERAPEUTIC LEVEL: 8-15
Aminophylline (Theophylline)
Antiallergic (histamine inhibitor); stabilizes mast cell membranes
ADRs: THROAT IRRITATION
Used for ASTHMA PROPHYLAXIS; comes in MDI or Turbo inhaler, nasal spray, & ophthalmic sol’n
RINSE MOUTH AFTER USE
Useful for children and with Exercise Induced Asthma (EIA)
Cromolyn sodium (Intal)
Leukotriene receptor antagonist; blocks inflammatory response by leukotrienes
ADRs: GI, headache, ELEVATED LIVER FUNCTION TESTS
MAINT. THERAPY & prophylaxis of asthma; not good for acute attack
With warfarin –> inc warfarin levels
In combo with aspirin –> inc. ____ levels
Take 1hr before or 2hrs after meals
Zafirlukast (Accolate)
Inhaled CORTICOSTEROID; blocks inflammatory enzymes
ADRs: Hoarseness, dry mouth, THRUSH
Can have systemic steroid response; LONG- TERM TX of asthma; RINSE MOUTH
Also: Advair, Dulera, Breo
Beclomethasone (Vanceril)
Antitussive, non-opioid; suppresses cough center; NO analgesic or addictive properties
ADRs: Infrequent; GI distress and drowsiness
Synthetic opiate derivative w/o analgesic and resp. depressant effects
Dextromethorphan (DM)
Decongestant; alpha & beta stimulation releases norepi
Vasoconstriction, bronchial muscle relaxation, dec. uterine activity, shrink mucous membranes
ADRs: Minimal; CV (tachycardia, flushing)
AVOID TAKING NEAR BEDTIME d/t stim. effects
Pseudoephedrine (Sudafed)
Antihistamine; bronchodilation, vasodilation
Inhibits release of acetylcholine
Sedative effects –> used as a HYPNOTIC
ADRs: *SEDATION, dizziness, LASSITUDE, blurred vision, EUPHORIA; dec. appetite, N/V/D, dry mouth; urinary freq., palpitations, TINGLING/WEAKNESS OF HANDS)
May cause allergic DERMATITIS
Do NOT take with alcohol; tolerance can occur; used as a hypnotic for kids and adults
Diphenhydramine (Benadryl)
Anti-lipid; prevents formation of cholesterol
ADRs: mild, transient GI disturbances, headache, sleep disturbances, Inc. transaminase levels, peripheral neuropathy, lupus-like syndrome, SEVERE MYALGIA, muscle weakness, RHABDOMYOLYSIS
CAUTION IN ALCOHOLICS & LIVER DISEASE
Monitor liver function tests; contraindicated in pregnancy, enhance effects of anticoagulants
GRAPEFRUIT JUICE INHIBITS METABOLISM–> toxic levels of drug
Atorvastatin (Lipitor)
Sympatholytic, antihypertensive, a2 adrenergic agonist; reduces NE; dec. peripheral resistance
ADRs: ORTHO HYPOTENSION, sedation, DEPRESSION, dry mouth, dec. WBC & PLT, sexual dysfunction; Na & water retention (unless on diuretic)
CONTRAINDICATED IN LIVER Dx and MAJOR DEPRESSION
Can be used for pregnancy induced HTN (PIH)
Methyldopa (Aldomet)
Antihypertensive, a1 adrenergic antagonist; prevents constriction (vasodilation & dec. PVR)
ADRs: ORTHO HYPOTENSION; dizziness, SYNCOPE, tachycardia, peripheral edema, impotence
FIRST DOSE PHENOMENON (severe drop in BP!)
Prazosin (Minipress)