Myositis Flashcards
Statin associated myopathy autoantibodies
Anti-HMCCR ab - very specific
Associated with HLADRB1*11:01
Inclusion body myositis features
Men>women, onset 50-60
Distal UL (finger flexors, wrist,non dominant more affected),Proximal LL-quadriceps wasting
Dysphagia in upto 50%
Auto antibody in IBM
anti-CN1A, 5NT1A
Auto antibody in myositis associated with ILD
Anti-MDA5
Auto antibody associated with calcinosis
NXP2
Autoantibody associated with malignancy
anti-T1F1 gamma
Autoantibodies associated with dermatomyositis
Anti- Mi-2 (classic DM)
Anti -SAE
Necrotising myopathy associated autoantibody
anti-SRP
Anti-synthetase syndrome
Myositis, ILD, arthritis, Raynauds, ‘mechanics hands’’
Anti -Jo1, anti-Zo, OJ , PL-12, KS, PL-7, EJ, Ha
IgG4 disease and related diseases
Autoimmune pancreatitis
Lymphocytic infiltrate, storiform fibrosis
Mikulicz syndrome
Reidels thyroiditis
Retroperitoneal fibrosis (Ormonds disease)
Periaortitis and periarteritis
Cogans syndrome features
Inflammatory disease affecting eye and inner ear
Recurrent Menieres and interstitial keratitis
Behcets disease features
Relapsing oral and genital ulcers, bilateral posterior or pan uveitis,Non erosive monon or oligo arthritis, vasculitis
Pathergy
HLA-B*51 strongest genetic factor
Groove sign characteristic for which condition
Eosinophilic fascitis
Tenderness in arms,blistering,peripheral eosinophilia
suggests which condition
Bullous pemphigoid
Skin manifestations in Dermatomyositis
Gottrons rash/papule over MCP and PIP joints Heliotrope rash over upper eye lid Shawl sign over chest and back Periungal changes Mechanics hands
CK normal
