Myositis Flashcards

1
Q

idiopathic inflammatory myopathies

A

rare autoimmune diseases usually presenting with progressive, symmetrical, proximal muscle weakness

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2
Q

idiopathic inflammatory myopathies are characterised by

A

elevated CK, abnormalities on MRI and evidence of an irritative pattern on EMG

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3
Q

definitive diagnostic test for idiopathies inflammatory myopathies

A

muscle biopsy

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4
Q

dermatomyositis clinical features

A

any age
F > M
proximal
CK+++ x50

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5
Q

dermatomyositis biopsy

A

perimysial and perivascular inflammation

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6
Q

dermatomyositis associations

A

malignancy
ILD
connective tissue disorders
calcinosis in children

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7
Q

polymyositis clinical features

A

adults
F > M
no rash
proximal
CK+++ x50

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8
Q

polymyositis biopsy

A

inflammation
surrounding and invading muscle fibres

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9
Q

polymyositis associations

A

interstitial lung disease
autoimmune ddisorders
cancer

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10
Q

inclusion body myositis (IBM) clinical features

A

elderly
M > F
no rash
finger flexors, knee extensors
dysphagia
CK+ x20

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11
Q

inclusion body myositis biopsy

A

rimmed vacuoles (inclusion bodies)
inflammation surrounding and invading muscle fibres

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12
Q

inclusion body myositis associations

A

autoimmune disorders
poorly responsive to immunosuppressant therapy

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13
Q

necrotising autoimmune myositis clinical features

A

adult and older
F > M
proximal
CK+ x10

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14
Q

necrotising autoimmune myositis biopsy

A

necrotic muscle fibres with absence of inflammation

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15
Q

necrotising autoimmune myositis associations

A

malignancy
connective tissue disease
drug induced

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16
Q

MRI for myositis

A

diffuse and patchy test to confirm diagnosis, exclude other conditions and distinguish dermatomyositis from polymyositis

17
Q

anti synthetase antibodies

A

associated with a subgroup of polymyositis with high incidence of interstitial lung disease, mechanics hands and raynauds

18
Q

anti signal recognition particle

A

strong association with aggressive necrotising myositis and poor response to steroid treatment

19
Q

anti Mi-2 antibody

A

strong association with acute polymyositis and dermatomyositis with good response to treatment wth immunosuppressants