Autoimmunity Flashcards
two types of immune response
innate response
adaptive response
phagocytosis cells
granulocytes, macrophages, monocytes
mediator releasing cells
eosinophils, basophils, mast cells
soluble proteins in immune system
complement factors
acute phase proteins
cytokines
chemokine
role of T lymphocytes
antigen recognition
activate macrophages
kill virus infected cells
role of b lymphocytes
antibody production
antigen presentation to T cells
define immunological tolerance
the ability to not create an immune response to an antigen
natural or self tolerance
it is wrong to attack the body’s own proteins and other antigens
induced/adaptive tolerance
tolerance to external antigens: protect us from allergic reactions to things like food, pollen etc.
immunologically privileged
eg. uterus carrying a foetus
contains foreign antigens from the father but site has subdued immune responses
reasons immune system might regard self antigen as foreign
changed self (virus/toxin)
changed immune system sensitivity/specificity
2 types of autoimmune processes that may set of inflammatory process
- antibody against self
- effector T cell activated against self
when autoimmune processes cause inflammatory response
complement/cytokine activation
autoimmune disease
does the presence of an autoantibody imply a disease state
no
increased level of autoantibodies with age
all systemic autoimmune diseases are diagnosed based on
clinical findings with only SUPPORT from relevant autoantibody presence
