MYOGLOBIN AND HEMOGLOBIN

Question 1

n iron-containing cyclic

tetrapyrrole linked by methyne bridges

Answer 1

heme

Question 2

resides at the center of the planar tetrapyrrole.

ferrous or ferric

Answer 2

ferrous iron (Fe
2+)

Question 3

proteins with metal-containing tetrapyrrole prosthetic groups

Answer 3

cytochromes (Fe and Cu) and chlorophyll (Mg)

Question 4

Angle of bond that links the O2 and myoglobin

Answer 4

121

Question 5

Angle that separates the 2 atoms of oxygen and electrons that are coplanar

(Left)

Answer 5

120

Question 6

Separates the pairs of electron and triple bonds that are arranged in linear fashion

(Right)

Answer 6

180•

Question 7

The oxygen-binding curve for myoglobin

Answer 7

Hyperbolic

Question 8

Load O2 readily at PO2 of lung capillary bed (100mmHg)

Myoglobin or hemoglobin?

Answer 8

Myoglobin

Question 9

Amount of Bound O2 at PO2 released in active muscle

Answer 9

20mmHg (capillary; active muscle)

40mmHg (other tissues; mixed venous O2 tension)

100mmHg (arterial)

Question 10

mmHg of of PO2 released during strenous exercise

Answer 10

5 mmHg (required for cytochrome oxidase)

Question 11

(HbA; normal adult hemoglobin)

Answer 11

α2β2

Question 12

(HbF; fetal hemoglobin)

Answer 12

α2γ2

Question 13

α2βS2

Answer 13

(HbS; sickle cell hemoglobin)

Question 14

HbA2
; a minor adult
hemoglobin

Answer 14

α2δ2

Question 15

hemoglobin to maximize both the
quantity of O2
loaded at the PO2 of the lungs

Answer 15

cooperative

binding

Question 16

values of P50
for HbA and
HbF are 26 and 20 mm Hg

Answer 16

P50

-partial pressure of O2

Question 17

a hemoglobin that carries CO2 to venous blood

Answer 17

carbamates

Question 18

formed in erythrocytes by the hydration of CO2
to carbonic acid (H2CO3)

cabonate or bicarbonate ?

Answer 18

bicarbonate

Question 19

changes the charge of amino terminal

Answer 19

carbamate

Question 20

coupling of the interconversion of CO2 and H2CO3

Answer 20

Bohr effect.

Question 21

drives the conversion of bicarbonate to carbonic acid

His 146 or His 147 ?

Answer 21

his 146

Question 22

stabilizes deoxygenated (Tstate) hemoglobin by forming additional salt bridges that must be broken
prior to conversion to the R state.

Answer 22

BPG

Question 23

A mutation that compromise biologic function

HEMOGLOBINOPATHY or thalassemia?

Answer 23

hemoglobinopathy

Question 24

the heme iron is ferric rather than ferrous

methemoglobinemia or hemoglobinuria

Answer 24

methemoglobinemia

Question 25

tissue hypoxia with increased RBC

Answer 25

polycythemia

Question 26

nonpolar amino acid valine has replaced the polar surface

residue Glu6 of the β subunit

Answer 26

Hemoglobin S “STICKY PATCH”

Hb A also provides sticky patch

Question 27

Treatment for sickle cell disease

Answer 27

Inducing HbF expression to inhibit the

polymerization of HbS,

Question 28

myoglobin released in urine following myocardial infarction

Answer 28

myoglobinuria

Question 29

the partial or total
absence of one or more α or β chains of hemoglobin

myoglobinuria or thalassemia ?

Answer 29

Thalassemias

Question 30

remains in blood for 6-8weeks.

for DM

Answer 30

GLYCATED HEMOGLOBIN (HbA1c)

Question 31

a consequence of cooperative interactions
in the tetramer

sigmoid or myoglobin

Answer 31

Sigmoidal hemoglobin

Question 32

organic molecules that
contain four five-membered heterocyclic
(pyrrole) rings, linked in a cyclic or linear
array.

TETRAPYRROLES or trigly

Answer 32

TETRAPYRROLES

Question 33

One binding of O2 in one subunit
permits successive and easier
binding of O2 for other subunits

Answer 33

ALLOSTERIC EFFECT

Question 34

affinity of Hb for H+ and CO2 is affected by

changes in Hb-O2 saturation

Answer 34

HALDANE EFFECT

Question 35

Dec. O2 and pH, Inc. CO2

Answer 35

Bohr effect

Question 36

Dec. O2 and pH, Inc. CO2

Answer 36

Bohr effect

“tissue”

Question 37

Dec. CO2, INC. O2 and pH

Answer 37

Haldane effect

“lungs”

Question 38

Caused by the uptake of O2 in the lungs.

Answer 38

Haldane Effect

Question 39

His F8 is replaced by tyrosine

Forms a tight ionic complex that stabilizes Fe3+ state

Answer 39

Hemoglobin M

Question 40

an odorless, colorless gas, which can cause sudden illness and
death, is produced any time a fossil fuel is burned.
CO gas is readily absorbed and is unchanged by the lungs

Answer 40

CARBON MONOXIDE