2nd ASSESSMENT Flashcards
Animal starch
glucose or glycogen ?
glycogen
o SIMPLEST SUGAR
o building blocks of carbohydrates
o cannot be hydrolyzed into simpler
monosaccha
3-7 Carbon Atom
- Source: hydrolysis of lactose
- Synthesized in mammary gland for synthesis of lactose in milk
- Constituent of glycolipids and glycoprotein
- Medical: CATARACTS
fructose or galactose ?
Galactose
depends on aldehyde (hemiACETAL) or ketone group (hemiKETAL)
acyclic or cylcic
acyclic forms
basis for urine test of glucose
Aldose (hemiACETAL)
Pyranose o with Pyran ring (six-carbon ring) o Glucose (99% pyranose) Furanose o with Furan ring (five-carbon ring)
cyclic forms
• constituent of hyaluronic acid
o D-glucosamine
• constituent of chondroitin
o D-galactosamine (chondrosamine)
Glucose + glucose
Source:
• Hydrolysis of starch (amylase)
• Germinating cereals and malt
maltose or lactose ?
maltose
• glucose and fructose
• source:
o cane, beet sugar, sorghum, fruits and veges
maltose or sucrose ?
sucrose
source:
• yeasts and fungi
• main sugar of insect
aldose or trehalose
trehalose
• In exoskeleton of crustaceans, insects, and mushrooms.
chitin
o Keto group in position 2
glucose or fructose ?
fructose
glucose: o Aldehyde at position 1
o Same molecular formula, but are different compounds
isomer or optical ?
isomer
(asymmetric carbon)
carbon is attached to four (4) different types of atoms
chiral or achiral ?
chiral
(asymmetric carbon)
carbon is attached to four (4) different types of atoms
chiral or achiral ?
achiral
only GLYCINE!
most oxidized Carbon
anomeric or isomeric ?
ANOMERIC CARBON
mirror images of each other
example: D- and L- configurations of a sugar
enantiomer or aldehyde ?
enantiomer
Cyclic epimers at C-1 if it’s an aldose
C-2 if ketose
carbon or anomer?
anomers
intermediate in the uronic acid pathway
L-gulonate
- the entire complement of sugars
glycome
- fruits
- polymer of galacturonic acid
pectin
glycoprotein of human erythrocytes
glycophorin
o Attach α-amino group to α-carbonyl group of PROTEIN
Peptide bond (trans configuration)
folding of short (3-30) amino acid residues
Stabilized by excessive hydrogen bonding
PRIMARY or SECONDARY LEVEL OF AA
SECONDARY
•Alpha-helix
R -handed spiral
H Bond: Parallel to helix
•Beta-pleated sheets
H Bond: Perpendicular sheet
Secondary helix example: •Keratin, Hemoglobin
alpha or beta ?
alpha
Secondary helix example: • Amyloid (Alzheimers) Immunoglobulins
beta
what are the aliphatic nonpolar side chain?
GAVIL
Glycine Alanine Valine Isoleucine Leucine
o Only amino acid with an achiral carbon
o Used in purine synthesis and first step of heme synthesis: Glycine + Succinyl CoA D-ALA
o Major inhibitory neurotransmitter in the SPINAL COR
GAVIL
GLYCINE
metabolites accumulate in MSUD (Maple Syrup Urine Disease)
VIL
VALINE, iSOLEUCINE, LEUCINE
o No charge (a weak base)
o Used in the diagnosis of Folic Acid Deficiency
• Increase N-formiminoglutamate (FIGU) Excretion Rate in URINE
Basic “HAL” acceptor
Histidine
o Precursor of Urea, Creatinine and Nitric Oxide
o Made in the body.
Basic “HAL” acceptor
arginine
the 21st amino acid
An L-α amino acid found in proteins
Selenocysteine
o a total net charge of Zero
o Predominates pH at Isoelectric pH or Isoelectric Point (AA is uncharged)
Zwitterion Molecule
essential AA
PVT TIM HALL
- Phenylalanine, Valine, Tryptophan, Threonine, Isoleucine, Methionine, Histidine, Arginine, Leucine, Lysine
- Conditional essential AA
Arginine and Histidine
o Largest aromatic
o Precursor for Niacin, Serotonin and Melatonin
AROMATIC HPTT
TRYPTOPHAN (W)
The only nonpolar imino group
proline
-Contributes to fibrous structure of collagen
- Precursor of Homocysteine
- Transfer of methyl groups as SAM
-SH CM group
methionine
Hydrophobic; lipophilic ; Fat-soluble vitamins
Soluble in ESTHER and CHLOROFORM
Lipids or urea ?
lipids
Hydrophobic; lipophilic ; Fat-solunle vitamins
Soluble in ESTHER and CHLOROFORM
-o choline nitrogen-containing base
lipid or phospholipid ?
phospholipid
fatty acids + sphingosine + carbohydrate
lipid or glycolipid ?
glycolipid
ALIPHATIC CARBOXYLIC ACIDS
- esterified in oil/wax
- unesterified in blood
fatty acid or amino acid
fatty acid
even carbon atom “16-20”
More hydrogen atoms, higher is its melting point
SOFT SOLID at RT
saturated or unsaturated
SATURATED (BAD FAT) “palmitic acid”
temperature:
low: zigzag
high: rotate
the first member of the SATURATED (BAD FAT)
acetic acid
More double bond, lower melting point
saturated or unsated ?
unsaturated “elaidic acid”
a cis-bond that:
“bent” 120° at the double bond
V-shaped
oleidic or arachidonic
oleidic acid
o 4 double bond bent in U shape
oleidic or arachidonic
arachidonic acid
o found in margarine “artificial butter”
linoleic acid or trans-linoleic acid ?
Trans-linoleic acid / trans-fatty acid
(found in vegetable oil)
linoleic acid or oleic acid
linoleic acid “polyunsaturated”
causes bronchoconstriction / asthma
leukotrienes or lipoxins ?
leukotrienes
- anti-inflammatory for chronic disease, CVD as well as for cancer, rheumatoid arthritis and Alzheimer disease.
Omega-3 Fatty Acid
o precursor of Steroids
cholesterol or trigly?
cholesterol
- Friedrich Meischer (1868)
- Allows transfer of genetic information (stored in nitrogenous base) form one generation to the next.
NUCLEIC ACID
o Basic Unit of Nucleic Acids
o sugar + nitrogenous base + phosphate group
AMINE or NUCLEOTIDE
NUCLEOTIDE
sugar attaches to the N-9 (purine) of base
SYN OR ANTI?
SYN
sugar attaches to the N-3 of base
SYN OR ANTI ?
ANTI
o Are nitrogen-containing heterocycles
PURINE (Bicycle) AND PYRIMIDINE (mono)
a member of vitamin B-complex
thymine or thiamine
thiamine
- isomeric molecules that differ in structural formula but with same chemical formula
Tautomers or Camp
Tautomers
o primary PO4 acceptor in oxidative phosphorylation, cellular respiration and muscle contraction
adp
- primary methyl donor of the body in virtually all known biological methylations
- Plays an important role in Detoxification
- Breaks down to Homocysteine
S-Adenosylmethionine (SAM)