Myeloproliferative neoplasms Flashcards
Which of the following is NOT considered a myeloproliferative disorder?
Lymphoma
Essential thrombocythemia
Primary myelofibrosis
Polycythemia vera
Lymphoma
Which of the following genes is most commonly found to be mutated in myeloproliferative disorders?
NF1
MEN1
MPL
JAK2
CALR
JAK2
What role does the JAK2 protein play within hemopoietic cells?
Signal transcription
Signal transduction
Signal initiation
Signal elimination
Signal re-entry
Signal transduction
In patients with essential thrombocytosis who do not have a JAK2 mutation, what gene is most commonly mutated?
MEN1
BRCA
Calreticulin
NF1
CFTR
Calreticulin
Which of the following is NOT a common sign or symptom of polycythemia vera?
Pruritus (aquagenic- when they bath)
Headaches
Enlarged spleen
Plethoric faces
Fever
Fever
Which of the following is NOT part of the treatment of polycythemia vera?
Venesection
Hydroxycarbamide
JAK2 inhibitors
Sirolimus
Sirolimus
Which of the following is part of the treatment protocol for essential thrombocytosis?
Vincristine
Cyclophosphamide
Vinblastine
Methotrexate
Interferon
Interferon
What is the pathology causing illness in primary myelofibrosis?
Enlargement of the spleen
Production of red blood cells in the liver
Necrosis of the bone marrow
Decreased red blood cell lifespan
Fibrosis of the bone marrow
Fibrosis of the bone marrow
Which of the following finding is NOT suggestive of the diagnosis of multiple myeloma?
Clonal proliferation of plasma cells
Hypocalcemia
Decreased renal function
Lytic bone lesions
Anemia
Hypocalcemia
Which of the following findings, commonly seen in the peripheral blood film of patients with multiple myeloma, is due to increased antibody levels in the blood?
Tear drop cells
Proliferation of plasma cells
Rouleux formation
Leukoerythroblastic blood picture
Anemia
Rouleux formation
Which of the following techniques can be used to detect paraproteins in the blood of a patient with multiple myeloma?
ELISA
Peripheral blood smear
Serum electrophoresis
Western blot
Nephlometry
Serum electrophoresis
Which of the following statements regarding monoclonal gammopathy of undetermined significance is FALSE?
A. Patients with Monoclonal gammopathy of undetermined significance can progress to multiple myeloma
B. Plasma cell inhibitors are given to patients with Monoclonal gammopathy of undetermined significance
C. There is a low paraprotein level in patients with Monoclonal gammopathy of undetermined significance
D. Patients do not show any signs of clinical damage in Monoclonal gammopathy of undetermined significance
B. Plasma cell inhibitors are given to patients with Monoclonal gammopathy of undetermined significance
Which of the following agents is NOT usually used to treat patients with multiple myeloma?
Melphalan
Dexamethasone
Bortezomib
Lenalidomide
Docetaxel
Docetaxel
Pancytopenia is usually seen in _____
Primary myelofibrosis
