chronic lymphoid leukemia Flashcards
Which of the following is the MOST common presentation of chronic lymphoid leukemia?
A. Patient notices swollen glands in the neck
B. Life threatening infection
C. Elevated lymphocites noted on labs ordered for other reasons
C. Severe bleeding
D. The patient develops indigestion and examination shows a greatly enlarged spleen
C
What is the treatment for chronic lymphocytic leukemia?
A. Bone marrow transplant
B. Radiotherapy
C. Surgical removal
D. A combination of chemotherapy and antibodies directed to B cells
D. A combination of chemotherapy and antibodies directed to B cells
Which of the following CD markers are positive in chronic lymphocytic leukemia?
A. CD 5+ and CD 21+
B. CD 3+ and CD 15+
C. CD 10+ and CD 20+
D. CD 8+ and CD 21+
E. CD 5+ and CD 23+
E. CD 5+ and CD 23+
Which B-cell receptor signalling pathway is blocked in order to inhibit the proliferation signals produced by tumor cells?
K-ras
WT1
BTK
PTEN
p53
BTK
Which of the following is NOT associated with chronic myeloid leukemia?
Fever
Sweats
Massive splenomegaly
Calcium pyrophosphate
Gout
Calcium pyrophosphate
Which of the following is a characteristic feature of the blood smear in chronic lymphocytic leukemia?
Cells with basophilic stippling
Increased myeloblasts
Cells with nuclear inclusions
Increased prolymphocytes
Smudge cells
Smudge cells
What causes the characteristic appearance of smudge cells?
A. Pressure from the surrounding cells causes rupture of the fragile cytoplasm of cells
B. Accumulation of the mutations causes rupture of the fragile cytoplasm of cells
C. Preparation artifact causing rupture of the fragile cytoplasm of cells
D. Self destruction by apoptosis leads to rupture of the fragile cytoplasm of cells
E. Swelling of the cells causes rupture of the fragile cytoplasm of cells
C. Preparation artifact causing rupture of the fragile cytoplasm of cells
(Acute/Chronic) leukemia is defined as a neoplastic proliferation of mature-appearing circulating lymphocytes.
Chronic
Chronic lymphocytic leukemia
is a type of
leukemia
associated with _______ on peripheral blood smear.
“smudge cells”
Enlargement of the (organ) ____________
due to extramedullary hematopoesis is often associated with
chronic myelogenous leukemia
spleen (splenomegaly)
Chronic myelogenous leukemia
is associated with a(n) (increase/decrease) _____ in red blood cell concentration.
decrease
Chronic lymphocytic leukemia is a type of leukemia that can transform into ________ lymphoma.
diffuse large B-cell
A _________ is a complication of chronic myelogenous leukemia involving acceleration of chronic myelogenous leukemia and transformation into acute myeloid leukemia or
acute lymphoblastic leukemia
blast crisis
( if they do not get treatment, progressed due to additional mutation)
Chronic myelogenous leukemia is associated with (high/low) leukocyte alkaline phosphatase concentrations.
low
CD5 and CD20 are the two surface receptors/markers expressed by naive B-cells
in
chronic lymphocytic leukemia
.
