Acute Leukemia Flashcards
Which of the following are typical characteristics of an acute leukemia?
A. Replacement of normal marrow elements by leukocytic blasts and bleeding episodes
B. Blasts and immature leukocyte forms in the peripheral blood and anemia
C. Leukocytosis
D. All of the above
D
_____ Myeloid and monocytic
M1
M4
M5
L1
M4
_____ Monocytic
M1
M4
M5
L1
M5
_____ Myeloid without maturation
M1
M4
M5
L1
M1
Characteristics of FAB M1 include
A. leukocytosis with maturation of the myeloid cell line in the peripheral blood
B. leukocytosis with maturation of the lymphocytic cell line in the peripheral blood
C. leukocytosis without maturation of the myeloid cell line in the peripheral blood
D. leukocytosis with many mature leukocytes in the peripheral blood
C. leukocytosis without maturation of the myeloid cell line in the peripheral blood
A common characteristic of ALL is
A. bone and joint pain
B. many blast cells with Auer rods
C. leukocytopenia
D. a leukemia of older persons
A
Specific nature B-cell surface marker(s) membrane is
A. CD 79a
B. CD19
C. CD 20
D. all of the above
D
Which one of the following drugs is NOT used in the treatment of acute lymphoblastic leukemia?
Daunorubicin
All trans retinoic acid
Asparaginase
Steroids
Vincristine
All trans retinoic acid
Which of these statements is NOT TRUE regarding acute myeloid leukemia?
A. It is caused by an inappropriate production of myeloblasts
B. Genetic analysis is valuable in predicting the outcome
C. It may develop from myelodysplasia
D. Stem cell transplantation is more effective when the stem cells are
taken from another person (not the patient)
E. Allogeneic bone marrow transplantation is only used in patients with low-risk disease
E
In which age group is acute lymphoblastic leukemia commonly seen?
20 - 30 years
30 - 40 years
40 - 60 years
2 to 8 years
60 - 80 years
2 to 8 years
Presence of which of the following genetic abnormalities is a bad prognostic factor for acute lymphoblastic leukemia?
t (8:14) translocation
High hyperploidy
t (1:19) translocation
t (12:21) translocation
t (9:22) translocation
t (9:22) translocation
Which of the following is a common site for relapse of acute lymphocytic leukemia?
Lungs
CNS
Kidneys
Skin
Liver
CNS
Which of the following cells is is seen in myeloid leukemia on a bone marrow aspirate?
Primitive myeloblasts
Lymphoblasts
Plasma cells
Promyelocytes
Metamyelocytes
Primitive myeloblasts
AML seen with which of the following chromosomal translocations is known to be associated with disseminated intravascular coagulation?
t (15:17) translocation
t (14:18) translocation
t (12:21) translocation
t (16:18) translocation
t (11:14) translocation
t (15:17) translocation
Which of the following is classically associated with all acute leukemias?
Hyperviscosity
Hemarthrosis
Bone marrow failure
Swollen lymph nodes
Massive splenomegaly
Bone marrow failure
