MYELOPROLIFERATIVE NEOPLASM DISORDERS

Question 1

⦿ Malignant hyperplasia of the multipotential myeloid stem cell causes increase in all cell lines (rbc, wbc, platelets)

⦿ High blood viscosity

A. Polycythemia Vera
B. Chronic Myelogenous Leukemia (CML)
C. Essential Thrombocythemia (ET)
D. Chronic Idiopathic Myelofibrosis

Answer 1

A. Polycythemia Vera

Question 2

⦿ Characterized by proliferation of megakaryocytes
⦿ Platelets >1000 x 109/L (Giant forms, platelet function abnormalities

A. Polycythemia Vera
B. Chronic Myelogenous Leukemia (CML)
C. Essential Thrombocythemia (ET)
D. Chronic Idiopathic Myelofibrosis

Answer 2

C. Essential Thrombocythemia (ET)

Question 3

⦿ Presents with proliferation of granulocytes

⦿ Bone marrow has an increased M:E ratio (myeloid:erythroid ratio) 25:1 – abnormal

A. Polycythemia Vera
B. Chronic Myelogenous Leukemia (CML)
C. Essential Thrombocythemia (ET)
D. Chronic Idiopathic Myelofibrosis

Answer 3

B. Chronic Myelogenous Leukemia (CML)

Question 4

⦿ LAP is low
⦿ Philadelphia chromosome t(9;22)
⦿ Blast crisis

A. Polycythemia Vera
B. Chronic Myelogenous Leukemia (CML)
C. Essential Thrombocythemia (ET)
D. Chronic Idiopathic Myelofibrosis

Answer 4

B. Chronic Myelogenous Leukemia (CML)

Question 5

⦿ Myeloid stem cell disorder characterized by proliferation of erythroid, granulocytic, and megakaryocytic
precursors in marrow with dyspoiesis
⦿ Progressive marrow fibrosis
⦿ Teardrop cells (RBC)

A. Chronic Idiopathic Myelofibrosis
B. Chronic Myelogenous Leukemia (CML)
C. Essential Thrombocythemia (ET)
D. Chronic Idiopathic Myelofibrosis

Answer 5

A. Chronic Idiopathic Myelofibrosis