Five subgroups of MDS using the FAB classification scheme

Question 1

⦿ Anemia that is refractory (not responsive) to therapy
⦿ Bone marrow blasts <5% and peripheral blasts <1%**

a. Refractory anemia with excess blasts (RAEB)
b. . Refractory anemia (RA)
c.Refractory anemia with ringed sideroblasts (RARS)
d. fractory anemia with excess blasts in transformation (RAEB-t)

Answer 1

b. . Refractory anemia (RA)

Question 2

⦿ Ringed sideroblasts comprise more than 15% of bone marrow nucleated cells
⦿ Dimorphic erythrocytes (found in Peripheral blood smear)

a. Refractory anemia with excess blasts (RAEB)
b. . Refractory anemia (RA)
c.Refractory anemia with ringed sideroblasts (RARS)
d. fractory anemia with excess blasts in transformation (RAEB-t)

Answer 2

c.Refractory anemia with ringed sideroblasts (RARS)

Question 3

⦿ Presents with leukocytosis
⦿ Bone marrow blasts 5-20% and peripheral blood blasts <5%
⦿ Absolute monocytosis >1.0 x 109/L

a.Refractory anemia with excess blasts in transformation (RAEB-t)
b. Refractory anemia with excess blasts (RAEB
c.Chronic myelomonocytic leukemia (CMML)

Answer 3

c.Chronic myelomonocytic leukemia (CMML)

Question 4

⦿ Trilineage cytopenias (low rbc, wbc, platelets

⦿ Bone marrow and peripheral blood blasts are the same as with CMML, but there is no absolute
monocytosis

a.Refractory anemia with excess blasts in transformation (RAEB-t)
b. Refractory anemia with excess blasts (RAEB
c.Chronic myelomonocytic leukemia (CMML)

Answer 4

b. Refractory anemia with excess blasts (RAEB

Question 5

⦿ Bone marrow blast >20% but less than 30%; peripheral blood blasts >5%

a.Refractory anemia with excess blasts in transformation (RAEB-t)
b. Refractory anemia with excess blasts (RAEB
c.Chronic myelomonocytic leukemia (CMML)

Answer 5

a.Refractory anemia with excess blasts in transformation (RAEB-t)

Question 6

WHO classification reassigns as an acute leukemia instead of a myelodysplastic syndrome

a.Refractory anemia with excess blasts in transformation (RAEB-t)
b. Refractory anemia with excess blasts (RAEB
c.Chronic myelomonocytic leukemia (CMML)

Answer 6

.Refractory anemia with excess blasts in transformation (RAEB-t)