Myeloproliferative Flashcards
1
Q
What mutation is assoc with myeloproliferative disorders?
A
JAK2 mutation
2
Q
what are the myeloproliferative disorders?
A
- Polycythaemia rubra vera
- Essential thrombocytosis
- Myelofibrosis
○ Fibrosis of bone marrow, spleen regains activity SMG
3
Q
What genetic marker assoc with CML?
A
Philadelphia chromosome
Most cases of CML start during cell division, when DNA is “swapped” between chromosomes 9 and 22. (translocation) Part of chromosome 9 goes to 22 and part of 22 goes to 9.The swapping of DNA between the chromosomes leads to the formation of a new gene (an oncogene) called BCR-ABL. This gene then produces the BCR-ABL protein, which is the type of protein called a tyrosine kinase. This proteincausesCML cells to grow and divide out of control.
