Misc

Question 1

What can parvovirus cause?

Answer 1

• Reticulocytopenia
  
  • Anaemia
  • Normal platelets / white cells

Ix:

    - IgM active infection 
- IgG immunity 
- PCR as well (polymerase chain reaction)

Question 2

What can cause pancytopenia?

Answer 2

• Alcohol
  
  • B12/folate (essential for DNA synthesis)
  • Acute leukaemias
  • Myelodysplastic syndrome
  • Hypersplenism

Question 3

What haematological effects does alcohol have?

Answer 3

• Thrombopoietin from liver is reduced, so platelets reduced
  
  • Iron deficiency - poor diet / variceal bleeding

Question 4

What bones are main sites of haematopoeisis?

Answer 4

- < 25 yo
		○ Femur and tibia
	- 20-70
		○ Vertebrae
		○ Pelvis
		○ Sternum
		○ Rib
	- BEWARE PAIN IN THESE SITES!

Question 5

Normal blast count on film?

Answer 5

<4% blasts in normal
4-20% blasts: myelodysplastic syndrome
>20% blasts: leukaemia

Question 6

What is neutropenic sepsis defined with?

Answer 6

neutrophil count < 0.5
having cancer Tx
temp OR consistent SSx

Question 7

how is neutropenic sepsis treated?

Answer 7

Tazocin +/- vancomycin
antifungal
reverse-barrier nursing