Myeloplastic Syndrom And Acute Myeloid Leukemia Flashcards
Myelodysplastic Syndrome
Heterogeneous group of clonal hematopoietic stem cell disorde
ExPlain Peripheral blood cytopenia
[ Hb < 100 g/L
ANC < 1.8 x109/L
Platelets < 100 x109/L]
Mostly affect in MDS is a … age group
Mostly affect elderly age group
The defect of MDs it could happen in …. and ….. stages
- myeloied progenirator
- blast cells
MDS classified by WHO to 6 main classifications????
- Number of dysplastic lineages
- Number of cytopenias
- % of blasts in peripheral blood and bone marrow
- % of ring sideroblasts
- Cytogenetic abnormalities
what are the 2 causes of ovalmacrocytic anemia
megaloblastic anemia and the other is MDS.
What is AML
Uncontrolled clonal proliferation and accumulation of immature myeloid cells (myeloblasts) in bone marrow, blood and/ or tissues causing bone marrow failure.
AML is a Heterogeneous disease clinically, morphologically and genetically.
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What is a disorder that cause the AML ??
Down syndrome)
> 20% blast cells in the bone marrow means that the patient have
AML
What is the indecation of finding a Auer rods
Aure rods are rod structure, when you see those rods in the cytoplasm of the blast cells so it is ALWAYS myeloblast it cant be lymphoblast, so it is acute myeloid leukemi
What is the imp of Immunophenotyping as a diognostic method ?????
To differentiate between acutemyeloidleukemia and acute lymphoid leukemia
Immunophenotyping is Rapid and sensitive diagnostic method ??
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Markers that we use to detect Myeloid
CD13, CD33, MPO
Markers that we use to detect Megakaryoblastic
CD41, CD61
