classification of hemoletic animie Flashcards
how can our body in general conpensate to the hemolytic animia
more RBCs production { erythropiosis}
why we check the reticylocyte count in case of hemolytic animia ???
bcs of the compensatry mechanisim in producing more RBCs but instead the retecylocyte the immature form is gonna released
the life span of RBCs is …
120
RBCs die in the …
1- liver
2- spleen
spleen
mention the types of hemolysis?
1- extravasculer
2- intravasculer
why the red colored urine is an indication for intravasculer hemolysis??
bcz the free Hb in the blood/urine has a red color
mention RBC Membrane Disorders
Hereditary Spherocytosis,Hereditary
Elliptocytosis
, immune mediated hymolisis
what is the important of comb test ??
auto-antibodies detection against RBCs
if a patient have G6DP defecincy and then ate a fave bean what gonna happened ????
SUFFER from hemyletic animia
if a patient have G6DP defecincy ang take antibiotic or got infected what gonna happen ??
provoke the symptom of hymolitic anemia
in thalasemia there is AN expanding frontal bone and hair like apperance in Xray ???why.
bcz the patient has a very sever hemolysis that the bone marrow expandeed to consompent
symptoms of sickle cell anemia only show up when ………
there is low oxygen
HbS is slower than the the Hb normal why ???
bcz in HBS there is less charge
in sckilll cell animia the spleen is small why ????
bcs the SCA will occlude blocking the blood supply to the spleen —-> spleen atrophy
SCA leads to the leg ulcer why?
bcs the SCA will occlude blocking the blood supply to the leg —> ulcer formation
SCA leads to gall stones { }
T
WHAT is the RBC component after broken down in the spleen normelly???
- Amino acids
- Fe( iron)
- Bilirubin
bilirubin.comes from
protoporphyrin
why bilirubin goes to the liver .
bcz it is Not soluble in water
so it will go to liver
in what form the RBCs are extravasculer hemyloteic ??
1- antibody coated hemylotic
2- irreguler shape
why having an intact membrane matters
Red cell is passing through very narrow vasculature. RBCs is very flexible and can reform and change
back into its original shape.
what gonna happened If the spherical loses its central pallor
it will be taken by the spleen
prematurely → if they stay in the
spleen with no glucose → They will
be hemolysed and anemia occurs
what are the Clinical course Hereditary Spherocytosisof
1- Hemolytic crisis
2- Aplastic crisis
Aplastic crisis affecting only … but .. an d… remains unbothered
- RBCs
- WBCs and platelets
G6PDdeficiency is an ….disease
X-linked recessive
the diseaese in whichHelmet cells ( Bite cells)
Patient with G6PD def → Oxidative Memrane damage
