Myeloma and Lymphoma

Question 1

How is multiple myeloma characterised?

Answer 1

Neoplastic proliferation of bone marrow plasma cells

Question 2

what charecteristics would you see in the bone profile when investigating myeloma without metasasis

Answer 2

high calcium

normal/high phosphate

normal alkaline phosphatase

Question 3

what does CRAB stand for in myeloma

Answer 3

high calcium
renal insufficiency
anaemia
bone pain

Question 4

at what ages does myeloma peak in incidence

1. 50-60 yrs
2. 60-70 yrs
3. 70-80 yrs

Answer 4

60-70 yrs

Question 5

what proteins in the blood would you investigate for in myeloma

Answer 5

IgG and IgA

Question 6

what can IgA and IgG proteins be found in myeloma

Answer 6

in the serum/urine

Question 7

what is another word for the IgG and IgA proteins that can be found in serum/urine in myeloma

Answer 7

Bence Jones proteins

Question 8

what lesions might you see when performing imaging on the myeloma patient

Answer 8

osteolytic lesions

Question 9

what is the main reason for hypercalcaemia in myeloma

Answer 9

increased bone reabsorption caused by local cytokines