Myeloma Flashcards
0
Q
What causes bone disease in myeloma?
A
Local activation of osteoclasts by plasma cells
1
Q
What are the possible patterns of secretion of plasma cells in myeloma?
A
- IgG with or without free light chains
- IgA with or without free light chains
- Free light chains only
- Other patterns of paraprotein
2
Q
What are the radiological manifestations of myeloma?
A
Generalised osteopaenia
‘Punched-out’ lytic lesions at site of plasma cell deposits
3
Q
What is a plasmacytoma and when is it seen?
A
Localized proliferations of plasma cells outside of bone
Seen in multiple myeloma
4
Q
What protein is found on urine electrophoresis in multiple myeloma?
A
Bence Jones Protein
