MYCOSES (Systemic mycoses)

Question 1

Other name of Histoplasmosis:

Answer 1

• Darling’s disease
• Spelunker’s disease
• Caver’s disease

Question 2

Causative agent of Histoplasmosis:

Answer 2

Histoplasma capsulatum
- NO capsule
- Source: bird, chicken, bat droppings (guano)

Question 3

Diagnostic features of Histoplasmosis:

Answer 3

Yeast-like cells within macrophages or lying free in extracellular spaces

Question 4

Other name of Coccidioidomycosis:

Answer 4

• San Joaquin Valley Fever
• Desert Rheumatism

Question 5

Causative agent of Coccidioidomycosis:

Answer 5

Coccidioides immitis
- major biohazard to laboratory personnel

Question 6

Diagnostic features of Coccidioidomycosis:

Answer 6

• Hyphae dissociated into ARTHROCONIDIA, BARREL-SHAPED
• Pathognomonic: Spherule (much larger than RBC) filled with endospores of Coccidioides.

Question 7

Other name of Blastomycosis:

Answer 7

• Gilchrist’s disease
• North American Blastomycosis

Question 8

Causative agent of Blastomycosis:

Answer 8

Blastomyces dermatitidis

Question 9

Diagnostic feature of Blastomycosis:

Answer 9

Single, broad-based bud (BBB)

Question 10

Other name Paracoccidioidomycosis:

Answer 10

South American blastomycosis)

Question 11

Causative agent of Paracoccidioidomycosis:

Answer 11

Paracoccidioides brasiliensis

Question 12

Diagnostic features of Paracoccidioidomycosis:

Answer 12

• Budding yeast of Paracoccidioides with “CAPTAIN’S WHEEL”/ “PILOT WHEEL” formation
  “Mariner’s wheel”/ “Mickey Mouse appearance”