MYCOSES (Subcutaneous mycoses)

Question 1

Also known as “Rose Gardener’s Disease”

Answer 1

Sporotrichosis

Question 2

Causative agent of sporotrichosis:

Answer 2

Sporothrix schenckii

Question 3

Sporothrix schenckii features:

Answer 3

• Dimorphic
• Cigar-shaped budding yeast that grows in branching hyphae with rosettes of conidia
• Lives in vegetation

Question 4

Tissue picture of Sporotrichosis:

Answer 4

Asteroid body
- central basophilic yeast cell surrounded by radiating extensions of eosinophilic material, which are depositions of antigen-antibody complexes and complement.

Question 5

Tissue picture of Chromoblastomycosis:

Answer 5

Sclerotic bodies
- Single or clustered, round, thick-walled, dark brown-black organisms that multiply by planate division
- Diagnostic of chromoblastomycosis

Question 6

Rare infection by dematiaceous fungi that invade organs of immunosuppressed hosts;
clinical findings: vary from solitary encapsulated cysts in the subcutaneous tissue to sinusitis, to brain abscesses
diagnostic feature: presence of brownish (melanized), septate hyphae within the lesions

Answer 6

Phaeohyphomycosis

Question 7

Granulomatous tumors of subcutaneous tissue; transmission is through traumatic inoculation;
Hallmark: Localized swelling and the formation of fistulae that contain hard granules composed of hyphae and inflammatory tissue (eg macrophages, fibrin)

Answer 7

Mycetomas