Mycology Flashcards
MOA of azole antifungals
inhibit ergosterol synthesis
allergiv bronchopulmonary aspergillosis
Aspergillus fumigatus
Aflatoxin causing liver cancer
Aspergillus flavus
Liver necrosis due to amanitin and phlloidin
Amanita mushrooms
Nonspecific agar for fungi
Saboraud’s agar (low pH inhibits bacteria)
Ringworms =
Dermatophytes
3 important dermatophytes
derMETophytes - Microsporum canis, Epidermophyton floccosum, Trichophyton tonsurans)
Green fluorescence on wood’s lamp
Ringworms (specifically microsporum)
Spaghetti and meatballs
Malassezia furfur (Tinea versicolor/An-an)
Rose gardeners
Sporothrix schenckii
DOC for Sporotrichosis
Itraconzole or Potassium Iodide
Mold in soil; SPHERULE in tissue
Coccidiodes immitis
Transmission of Coccidiodes immitis
inhalation of ARTHROSPORES (arthrospores form spherules filled with endospores)
DOC for coccidiodes
Amphotericin B or Itraconazole (fluconazole if with meningitis)
Bird droppings, Starlings, bat guano
Histoplasma capsulatum
2 forms of asexual spores of H. capsulatum
Tuberculate macroconidia(diagnostic) and microconidia (infective)
Histoplasma Hides inside Macrophages
develop into budding yeasts inside macrophages, spreads to liver and spleen
Name 2 great mimickers of TB
Histoplasmosis and Paragonimus
Round yeast with broad based buds
Blastomyces dermatitidis
Most common cause of fungal pneumonia
Blastomyces dermatitidis
Transmission of blastomycosis
inhalation of conidia
DOC for blastomycosis
Itraconazole (amphotericin if severe)