Mycobacteria: tuberculosis

Question 1

TB features

Answer 1

• Unicellular rods
• Gram +
• Complex cell wall (thick, waxy)

Question 2

Important glycolipid for TB

Answer 2

LAM - Lipoarabinomanann. Important virulence factor

Question 3

Clinical manifestations of TB

Answer 3

• Pulmonary infection

- Disseminated disease (15%) more common in childhood cases

Question 4

Role of inflammatory lesion in TB infection

Answer 4

• Created by immune cells to contain the infection

- Formed by immune response

Question 5

Types of TB granuloma (3)

Answer 5

1) Caseous
2) Non-necrotising
3) Fibrotic
May progress = cavitate to release contents and transmit

Question 6

Phagosome killing of M.tuberculosis

Answer 6

ROI and RNI induced by Interferon-y from T cells

Question 7

Survival in macrophages

Answer 7

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