my q's: aminoglycoside antimicrobials

Question 1

General info

Answer 1

• bacteriocidal (inhibit the growth of bacteria)
• MOA: enters through cell wall, bind to ribosomes, leading to transcription of incorrect proteins while also opening membrane pores to allow more aminoglycosides to enter
• highly ionised, not good oral absorption

NOT used in food production animals

Question 2

Side effects

Answer 2

• can be toxic if given in high concentrations leading to accumulation of the drug (have to be careful)
• causes otoxicity (hearing/balance problems) - vestibular in cats and auditory in dogs
• nephrotoxicity causing acute renal failure

Question 3

examples of aminoglycosides used in practice

Answer 3

1. gentamicin: used in conjunction with B-lactams, used in horses
2. neomycin: used for ear infections