Musculoskeletal Disorders Flashcards
Rheumatoid Arthritis - key characteristics
- insidious onset with morning stiffness + joint pain
- SYMMETRIC
- inflammatory polyarthritis
- extraarticular manifestations (nodules, pulmonary fibrosis, serositis)
- serum rheumatoid factor
- suspected RA dx in pts with systemic arthritis in 3+ joints
Rheumatoid Arthritis - symptomatology
- Joints (predominent sympotms): insidious, chronic, progressive, SYMMETRIC, multiple joints, morning stiffness, usually begins in small joints
- Rheumatoid nodules: extensor surfaces and over bony prominences
- Ocular: dry eyes and mucous membranes
- Other: palmar erythema, vasculitis (appears as tiny hemorrhage infarcts in nail folds)
Rheumatoid Arthritis - Deformities
- ulnar deviation
- boutonniere
- swan-neck
- hammertoe
Rheumatoid Arthritis - Diagnostics/workup
Lab - rheumatoid factor, anti-CPP antibodies (most specific for RA), ANA, ESR, CRP, CBC
- XR = most specific for RA!
- XR may look normal for first 6 months. Earliest changes noticed in hands and feet. Later imaging shows UNIFORM joint space narrowing + juxta-articular erosions!
- Arthrocentesis - to rule out other conditions like septic arthritis
Rheumatoid Arthritis - Management (Pharmacologic)
- DMARDS
- Methotrexate start at 75mg PO 1x/week and increase weekly (first-line), see results in 2-6 weeks. Large side effect profile (GI, cytopenia, hepatotoxicity)
- Sulfasalazine (second-line)
Rheumatoid Arthritis - acute vs. subacute vs. chronic
Acute - joint protection, pain relief, proper joint positioning, splinting, heat
Subacute - gradual increase in ROM
Chronic - protection, preserve ability to do ADLs, splits, orthotics, mobility aids, consult PT
Rheumatoid Arthritis - Referrals?
Rheumatologist - early, halt progression and initiate timely interventions
Surgery - advanced, improve function of damaged joints and relieve pain, last resort
Osteoarthritis - Key Characteristics
- deterioration of articular cartilage
- formulation of reactive new bone on articular spaces
- NO systemic symptoms
- Non-inflammatory arthritis
- pain RELIEVED BY REST, any morning stiffness is brief
Osteoarthritis - Risk Factors
- obesity (knee, hand, hip)
- contact competitive sports
- repetitive jobs
Osteoarthritis - Symptomatology
- insidious
- joint pain (exacerbated by activity)
- decreased ROM
- common joints: distal interphalangeal (DIP) joint, proximal interphalangeal (PIP) joint, carpometacarpal of thumb, hip, knee, metatarsal phalangeal (MTP) of big toe, cervical lumbar spine
Osteoarthritis - Exam Findings
- findings mostly limited to affected joint
- most don’t involve erythema or warmth
- may have limited ROM
- may palpate crepitus
- Heberden nodes: palpable osteophyte in DIP joints
- Bouchard nodes: hard outgrowths or gelatinous cysts on PIP joints
- NO SYSTEMIC MANIFESTATIONS!
Osteoarthritis - Diagnostics/workup
XR - joint space narrowing, unequal joint spaces, osteophyte formation/ lipping of marginal bone, thickened/dense subchondral bone
Arthrocentesis - to exclude other diseases
Osteoarthritis - Management (non-pharm)
- prevention! - weight reduction, normal vitamin D levels, focus on bone health
- heat and ice
- routine exercise
Osteoarthritis - Management (pharm)
- Acetaminophen (first line for mild) up to 4mg/day
- NSAIDs (interfere with platelet function and prolong bleeding)
Osteoarthritis - referral
Ortho - when you think pt is failing conventional, non-operative management. Surgery = last resort
Physiatrist (rehab/pain specialists) to help form non-pharm plan
Nutritionist - overweight and struggling to lose weight
Gout vs. pseudogout
gout - caused by monosodium urate monohydrate crystals
pseudogout - caused by calcium pyrophosphate crystals
Gout - phases
Initial - asymptomatic hyperuricemia (uric acid level in blood is high)
Acute gouty arthritis/ gout attack
Chronic arthritis
Gout - Primary vs. Secondary
Primary - hereditary
Secondary - acquired causes (diuretics, low dose ASA, CKD, hypothyroidism, etoh abuse)
Gout - Manifestations
- recurrent acute arthritis
- monarticular
- hyperuricemia (uric acid > 6.8 mg/dL)
Gout - Symptomatology
- acute onset, recurring, often nocturnal
- monarticular
- pedagra - MTP joint, most susceptible
- worsening pain as attack progresses
- fever
- swelling and redness
- tophi (crystal containing nodules)
Gout - Exam findings
- erythematous, edematous, hot, very tender joint
- tophi possible
Gout - Diagnostics/ workup
- Labs: uric acid > 6.8, WBC increased during acute attack
- arthrocentesis - if crystals are seen it is diagnostic for gout
- XR - may show findings consistent with gout but isn’t diagnostic
- Late XR - punched out erosions or lytic areas with overhanging edges
Gout - Management (non-pharm)
- activity, use as able, no bedrest
- dietary modifications (avoid high purine foods) - organ meats
- moderate high purine = seafood, veal, bacon, turkey, alcohol, soda, cheese
Gout - Management (pharm)
- NSAIDs (idomethacin 25-50 mg PO q8h (TID)
- Xanthine oxidase inhibitors (maintenance, chronic) = allopurinol 300-400 mg/day
Septic Joint/Arthritis - Key features
- ACUTE onset (hours)
- inflammatory monarticular arthritis
- commonly large weight-bearing joints
- large joint effusions
Septic Joint/Arthritis - risk factors
- bacteremia (IV drug use, endocarditis, other infection), damaged joints (RA), immunocompromised (DM, CKD, etoh, cirrhosis)
Septic Joint/Arthritis - common causative organism
- staphylococcus aureus
Septic Joint/Arthritis - symptomatology
- acute swelling, heat (hours)
- knee most common, hip, wrist, shoulder, ankle
- fever/chills
- impaired ROM
Septic Joint/Arthritis - Diagnostics/ workup
- arthrocentesis - rule out gout, always gram stain and culture, infected fluid usually yellow/green
- blood cultures x2 to rule out bacteremic origin
- CBC
Septic Joint/Arthritis - Management
- IV ANTIBIOTICS! -
- empiric, IV for 2 weeks
- Non-gonococcal: Vanco 1g q12h + 3rd gen. cephalosporin such as cephtriaxone 1-2g daily
- gonococcal: azithromycin 1g PO once + 3rd gen. cephalosporin such as cephtriaxone 1-2g/day
- MRSA/MSSA at least 4 weeks
- will need opioids early and taper to non-opioids
Septic Joint/Arthritis - Referrals
- PT for early PT and joint immobilization
- Surgery - effective drainage needs to occur
- infectious disease
Ankylosing Spondylitis - key characteristics
- MULTISYSTEM INFLAMMATORY DISORDER INVOLVING SI JOINTS AND AXIAL SKELETON
- progressive limitation of back motion and chest expansion
- young adults < 40
Ankylosing Spondylitis - Symptomatology
- insidious onset of low back pain (months)
- presence of symptoms > 3 months
- pain worse in morning/ with inactivity
- pain better with activity
- stooped posture, kyphosis (advanced)
- extra-articular manifestations (advanced)
Ankylosing Spondylitis - Workup
- Lab: serologic testing negative for rheumatoid factor and anti-ACC
- XR: most helpful in dx
- XR enthesitis - inflammation of enthuses (sites where ligaments and tendons inset into bone)
- XR Bamboo spine - seems to be fused vertically by briding of syndesmophytes
Ankylosing Spondylitis - Management (pharm)
NSAIDS (first line)
Ankylosing Spondylitis - Management (non-pharm)
PT - maintain function, postural training, exercise program
Ankylosing Spondylitis - Referrals
Rheumatology, ophthamology, GI, Cardio, surgery (ortho)
Surgery - tx focuses on fracture stabilization, fusion, joint replacements
Neuropathic Arthropathy - key characteristics
- progressive joint and soft tissue destuction of weight-bearing joints
- characterized by deformities, dislocations, fractures
- ankle and foot are most common
- normal muscle tone and reflexes are lost
Neuropathic Arthropathy - symptomatology
- enlarged, boggy (relatively) painless joint
- if pain, significantly less than one would expect
- instability and decreased ROM
- erythema, hot, joint effusion
Neuropathic Arthropathy - Workup
- ESR and CBC (help differentiate between this and osteomyelitis)
- XR used to stage, determine joint stability, identify osteopenia dislocations, fractures, etc.
Neuropathic Arthropathy - Management
- directed at primary disease (DM)
- acute phase - immobilization, stress reduction
- surgery (mainly for deformity management or amputation (deformity/destruction of tissues and DM)
Osteoporosis - key characteristics
- systemic skeletal disease
- characterized by low bone mass and deterioration of bone + increase in bone fragility
- hallmark = reduction in skeletal mass caused by an imbalance of bone formation and resorption