Musculoskeletal Flashcards

1
Q

what does the paraxial mesoderm form

A

Vertebral column + ribs
Dermis of the Back
skeletal muscles

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2
Q

What does the lateral plate somatic mesoderm form

A

Limb bones (scapula clavicle innominate)
dermis of the ventrolateral trunk and limbs
sternum

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3
Q

what is the dosrolateral region
what does it form

A

dermomytome
forms the dermis of the back and muscles of the limbs and trunk

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4
Q

what is the ventromedial region
what does it form

A

sclerotome
forms the vertebral columns and ribs

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5
Q

what type of mesnehcyme is the somite balls oringallly

A

segmented paraxial mesenchyme

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6
Q

where is the Noggin and Sonic the Hedgehog from

A

notochord and neural tube

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7
Q

what moves to surround the notochord and neural tube

A

scletomal

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8
Q

what does dorsal sclertome form Vertebral

A

vertebral arch of the vertebraew

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9
Q

hat does the ventral sclerotome surround the notochord and become

A

vertebral body

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10
Q

how do they form the bone

A

condense and form the cartilage

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11
Q

what is the von ebner’s fissure

A

the divdsion into a cranial and caudal portion of the sclerotome

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12
Q

what forms the annulus fibrousus

A

mesenchyme between the developing vertebrae

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13
Q

what does the notochord form

A

nucleus pulposus

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14
Q

what is the skeletal muscle from

A

paraxial mesoderm

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15
Q

what cells of what migrate ventrally DML + VLL

A

dorsomedial lip and ventrolateral lip of the demomyostome

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16
Q

what does this form

A

dermatome - dermis of the back
myotome - muscle precuros

17
Q

where do some cells also go
why

A

VLL migrate to somatic layer to access developing limbs

18
Q

where does the dermatome migrate

19
Q

what does the dermatome join with
to form what

A

and with lateral plate mesoderm forms dermis of the back and limbs

20
Q

what does the myotome differeiante into

A

dorsally epimere
ventrally hypomere

21
Q

what does the epimere do

A

instrinic back muscles (closer to ears)

22
Q

what is this inverated by

A

dorsal rami of the spinal nerves

23
Q

what is the hypomere do

A

lateral and ventral muscles of the thorax and abdomen and limb muscles

24
Q

what is it innverated by

A

ventral rami of spinal nerves

25
where do cells from the hypomere go
into developing limb buds
26
what do these divide into
anterior and posterior condensations on either side of the develop limb bones
27
what does the anterior condensation forms
Upper limb - flexor and pronator muscles Lower Limb Flexor and adductor muscles
28
what does the posterior condensations form
extensor and exntor for upper and lower limb (PEE) PSA accountment the kind is abdicated - posterior supinator abductor
29
what are the limb buds innverated by
primary rami of spinal nerves C5-T1 + L2-S3
30
what do the outpouching of the limbs form
ventrolateral body walls
31
what is the lateral plate mesoderm covered by
ectoderm
32
what induces the AER
lateral plate moderm cell
33
what is the progress zone
area of rapidly proliferating mesodermal cells
34
what singal does the WNT7a induce
underlying mesenhyme to become dorsal in nature