muscles Flashcards

1
Q

what are the 3 types of muscle

A

-smooth
-cardiac
-skeletal

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2
Q

what is smooth muscle

A

-contracts and relaxes automatically
-autonomic control
-not striped

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3
Q

what is cardiac muscle

A

-muscle of the heart
-myogenic - own electrical impulse
-contracts and relaxes automatically

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4
Q

what is skeletal muscle

A

-stripped appearance and voluntary muscle
-we have direct control over it

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5
Q

what a are skeletal muscles joined to the bone by and what are the types

A

tendons
-2 types of tendon

-origin - attaches muscle to the stationary bone
-insertion - attaches muscle to the bone that moves

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6
Q

how are muscles antagonistic pairs

A

-the muscle that contracts is the agonist/prime mover
-the muscle that relaxes is the antagonist
-one muscle that acts as an agonist for one movement acts as the antagonist for the opposite movement
-muscles can only contract and relax - they cannot push

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7
Q

what are muscles that cause joints to bend called

A

flexors

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8
Q

what muscle causes joints to straighten called

A

extensors

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9
Q

how do the biceps and triceps show antagonistic muscle action

A

-when bicep contracts - elbow joint bends
-at the same time the triceps relaxes and becomes longer
-when the triceps contracts it straightens the elbow joint and pulls the bicep to make it longer

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10
Q

what is the structure of the muscle

A

-main body is known as the muscle belly
-muscle belly is surrounded by a large layer of connective tissue - contains nerves and blood vessels and eventually forms tendons
-muscle belly made up of fasiculi - each fasiculus is a bundle containing long cylindrical muscle cells called muscle fibres
-can be up to 10-100 nm and 30 cm long

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11
Q

what is the membrane in a muscle cell known as

A

sarcolemma

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12
Q

what does each muscle cell contain

A

-sarcoplasm - cytoplasm of muscle cell
-many nuclei as each cell is formed from many cells fused tg
-many mitochondria to produce ATP
-glycogen stores for energy generation
-myoglobin stores for extracting oxygen from the blood
-protein fibres called myofibrils giving the muscle a striped appearance

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13
Q

what is the role of myoglobin

A

-to pick up oxygen from haemoglobin as it has a higher affinity for oxygen that Hb

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14
Q

what are the 2 things that make up myofibrils

A

-myosin
-actin

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15
Q

what is myosin

A

thick filaments that are 15nm in diameter
-around 200 joined tg
-has long tail and double head which can attach to binding sites on the actin
-heads contain ATPase which hydrolyses ATP into ADP and Pi
-the long tails form the bulk of the thick filament and the heads stick out from the surface
-when the myosin is relaxed the heads have ATP attached to them

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16
Q

what is actin

A

-thin filaments 7nm in diameter
-2 threads of actin coiled around each other
-at each twist there is a myosin binding site where myosin can become attached to the actin
-in relaxed muscle these binding sites are covered by two other proteins called troponin and tropomyosin - these can block the myosin binding sites

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17
Q

what is the actin and the myosin arranged into

A

-sacromeres - which is the smallest contracting unit of the skeletal muscle
-this causes a banding pattern which can be seen on an electron microscope

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18
Q

what are the colours of the bands of myofibrils that can be seen

A

-where myosin and actin overlap = dark band
-myosin only = lighter band
-actin only = even lighter band

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19
Q

what are the M and Z lines in a myofibril diagram

A

-Z is where the actin takes place
-M is where the myosin is anchored in place

20
Q

what are letters given to the bands in a myofibril diagram

A

-I band = actin filament only
-H band = myosin only
-A band = actin and myosin overlap
-sacromere = distance bwt the Z lines

21
Q

what is the theory given to muscle contraction

A

-sliding filament theory

22
Q

describe the sliding filament theory - detailed

A

-contraction is initiated by a nerve impulse arriving at a neuromuscular junction
-this causes the release of acetylcholine at the synapse of the neuromuscular junction
-this diffuses across the synaptic cleft and binds to specific comp receptors in the sarcolemma which is then depolarised
-the sarcolemma forms a series of infoldings called t-tubules and the wave of depolarisation spreads across these tubules and onto the sarcoplasmic reticulum inside the muscle
-the sarcoplasmic reticulum releases Ca2+ ions into the sarcoplasm this has 2 effects
-the Ca2+ ions change the shape of the troponin and tropomyosin causing them to fall of the actin filaments exposing the myosin binding sites
-the Ca2+ ions directly act on myosin activating it so that it breaks down the ATP via ATPase to release energy - this cause the myosin head to tilt forward towards the exposed binding sites on the actin filament
-cross bridges form bwt the myosin heads and the actin filaments
-as the cross bridges form the myosin heads rotates and they change position - the attached actin filament is pulled past the myosin - tis change in conformation of the myosin releases the bound ADP and Pi so the myosin returns to it starting position and attaches to the next binding site - known as ratchet movement
-actin filament is moved along by the myosin
-the actin filaments are detached from the myosin heads and both return to the original positions
-when this stops the Ca2+ ions are pumped back into the sarcoplasmic reticulum and troponin and tropomyosin move back to their original positions blocking the active site - the myosin can no longer bind so both the sacromeres move back to the original position and the muscle relaxes with the help of the antaganostic muscle

23
Q

what happens when the nerve impulse to the muscle stops

A

-the acetylcholine is released from the receptor on the sarcolemma by the action of acetylcholinesterase
-the sarcolemma then repolarises and Ca2+ ions are actively pumped back into the sarcoplasmic reticulum
-the levels of Ca2+ ion in the sarcoplasm falls and the troponin and tropomyosin move back into their original position blocking the binding sites`

24
Q

how does the increasing contraction of the sarcomere change the width of the A and H bands

A
  • A band widens
    -H band shortens
25
Q

how is each muscle connected to the nervous system

A

by motor neurons

26
Q

what is a motor unit

A

each motor neuron combined with the muscle fibres

27
Q

what does the number of muscle fibres in a motor unit depend on

A

the degree of control required by the muscle

28
Q

what is the volume of muscle fibres in a high degree of fine control

A

-motor neuron
-small or single number of muscle fibres

29
Q

what is the volume of muscle fibres without a high degree of fine control

A

many muscle fibres
-large muscles

30
Q

how does the all or nothing principle relate to muscle fibres

A

-either contracted or relaxed
-the nervous stimulus recived by the muscles fibres is either strong enoughj to bring about contraction or it isnt
-cannot partially contract
-if the nerve stimulation reaches a critical threshold level the fibres of the motor unit contract
-if not strong enought he motor unit does not respond

31
Q

what are the 3 ways in which the strength of muscle contarction be altered

A

-multiple unit stimulation
-temporal stimulation
-synchronisity of motor unit stimulation

32
Q

how does multiple unit stimulation work

A

-the more motor units activated the karger the proportion of the muscle which will contract therefore the more powerful movement

33
Q

how does temporal stimulation work

A

-the frequency with which the motor units are activated may vary

-muscle twitch occurs when the muscle fibres receive single nerve impulses which exceeds the threshold value then they respond by contracting then relaxing or twitching

-wave summation occurs when the second nerve impulse arrives before the muscle contraction has completed - the muscle fibres not have time to relax before the next contraction starts - add together effective;y to produce a more powerful summation

-muscle tetanus or tetanci contraction occurs went he nerve impulses arrive in quick succession then this leads to a more powerful contraction

34
Q

how does synchronisity of motor unit stimulation work

A

-Synchronised contraction occurs when all of the motor units contract simultaneously
-however this means all motor units will become fatigued at the same time and therefore activity can’t be sustained

-asynchronised contraction occurs when different motor units are activated at different times whilst some contract and some relax
-allows muscle activity to be sustained over an extended period of time at a sub-maximal level - so don’t fatigue

35
Q

describe the sliding filament theory - simpler

A

-action potential arrives at the neuromuscular junction, aceytlcholine diffuses across the gap and binds to a specific, complementary receptor which opens gated Na+ channels causing depolaristion of the sarcolemma
-the wave of depolarisation spreads down t-tubules causing release of Ca2+ ions from the sarcoplasmic reticulum
-Ca2+ binds to troponin and tropomyosin causing a change in shape moving it away from the actin and expose the myosin binding sites and causes the release of ADP and Pi from the hydrolysis of ATP
-myosin heads bind to actin forming cross bridges
-ADP/Pi falls of myosin causing it to tilt = Powerstroke
-pulls the actin past the myosin
-ATP binds to myosin head causing it to detach from the actin
-ATP is hydrolysed to ADP + Pi
-process repeats with myosin bidnign to next actin site

OVERALL - actin is pulled past the myosin shortening the sarcomere

36
Q

what are the two main types of muscle fibre

A

-type 1
-type 2

37
Q

what are type 1 muscle fibres

A

-slow twitch fibres
-smaller than type 2 and contract slowly
-dont fatidue as easily as fast ones
-so ideal for low intensity or endurance events
-maintain posture

38
Q

what are type 2 muscle fibres

A

-fast twitch fibres
-bigger size
-contract faster producing force more rapidly
-fatgue more easily so they are only useful for short distribution activities with high inensity

39
Q

type 1 slow twitch characteristics

A

-small size
-high myoglobin content - pick up lots of oxygen from blood for resp
-high capillary density
-high mitochondrial density -aerobic - oxygen is temrical electron acceptor
-high activity in low intensity
-low glycogen
-low phosphocreatin
-low fatigue
-slow contractile time
-slow relaxation
-slow activity during high intensity

40
Q

type 2 fast twitch fibre charcateristics

A

-large size
-low myoglobin
-low capillary density
-low mitochondrial density - anaerobic so glycolysis occurs which is in cytoplasm
-low activity in low intensity
-high glycogen store
-high phosphocreatin level
-high fatigue
-fast contractile time
-fast/high relaxation
-high activity in high intensity

41
Q

how is the pH of the muscles lowered in vigorous exercise

A

carbon dioxide is produced
which lowers it

42
Q

what do slow muscle fibres prefer carb load or creatine

A

carb load - glycogen store s- so more glucose - more aerobic resp

43
Q

how does creatine produce ATP

A

-creatine combines with a phosphate = phosphocreatine/ creatinephosphate
-this then combines with ADP to form ATP

44
Q

Give two reasons why transmission across a cholinergic synapse is unidirectional.

A
  1. (Only) the presynaptic
    neurone/knob/membrane releases/has
    neurotransmitter/acetylcholine;
    2.(Only) the postsynaptic
    neurone/membrane has receptors
    OR
    No receptors in the presynaptic
    neurone/membrane;
45
Q

how does temporal summation trigger a rapid response

A

(Several/repeated impulses in short
time) provide (enough)
neurotransmitter/acetylcholine to reach
threshold
OR
(Several/repeated impulses in short time)
so (enough) sodium ions enter to reach
threshold
OR
(Several/repeated impulses in short time)
increases membrane potential to reach
threshold;