Muscle relaxants Yusuf Flashcards
1
Q
Succinylcholine dose:
A
0.6mg/kg
0.5 - 1 min onset
Lasts for 5-10mins
2
Q
Metabolism of succinylchline:
A
- Is carried out by plasma cholinesterase produced in the liver
- Severe liver disease, potent anticholinesterases and certain chemotherapeutics reduce cholinesterase activity
3
Q
Succinylcholine adverese effects:
A
- Cardiac dysrhythmias -USE ATROPINE TO DECREASE THIS EFFECT
- Hyperkalemia
- Myalgia
- Myoglobinuria
- Increased intraocular pressure
- Increased intragastric pressure
- Increased intracranial pressure
- Trismus
4
Q
NDMR Classification:
A
- Short-acting - Mivacurium
- Intermediate - Atracurium, vecuronium, rocuronium
- Long - D-tubocurarine, metocurine, gallamine, pancuronium, pipecuronium, doxacurium
5
Q
Mivacurium dose:
A
- Intubation - 0.07mg/kg
- Infusion 0.4-0.6mg/kg/h
6
Q
Do NDMR’s cause histamine release?
What alters NDMR response?
A
- YES, HISTAMINE RELEASE
- Drugs (VA’s, aminoglycosides, magnesium, local anesthetics, Calcium blockers antiarrhythmics - enhance NMDR effect
- Hypothermia prolongs NM blockade
7
Q
Atracurium is eliminated by _____ elimination.
A
Hoffman
8
Q
Suggamadex is a reversal drug for?
A
NDMR drugs
