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PHARM > Muscle Relaxants > Flashcards

Muscle Relaxants Flashcards

1
Q

Non-depolarizing NMB drugs are reversed by

A

AChE inhibitors

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2
Q

Side effects of non-depol NMB toxicity?

A

DUMBBELSS

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3
Q

What antibiotic interacts w/ non-depol NMB?

A

Aminoglycosides

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4
Q

What are the isoquinoline derivatives of non-depolarizing NMB?

A

Atracurium, cisatracurium, doxacurium, mivacurium, tubocurarine

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5
Q

What are the steroid derivatives of non-depolarizing NMB?

A

Pancuronium, pipercuronium, rocuronium, succinylcholine

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6
Q

What is the short acting isoquinoline derivative?

A

Mivacurium

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7
Q

What has the most rapid onset for steroid NMB drug?

A

Rocuronium

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8
Q

What steroid NMB is practical for securing the airway rapidly?

A

Succinylcholine

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9
Q

What are the central acting spasmolytics?

A

Baclofen, Carisprodol, Chlorzoxazone, Cyclobenzaprine, Diazepam, Tizanidine

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10
Q

What are the non central acting spasmolytics?

A

Dantrolene

Botulism

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11
Q

What are the immuno drugs for MS?

A

Glucocorticoids
Glatiramer acetate
INF-B1a/b
Mitoxantrone

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12
Q

Baclofen

A

Central spasmolytic

GABA-B receptor agonist => hyperpolarize

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13
Q

Carisprodol

A

Very addictive

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14
Q

Chlorzoxazone

A

Central spasmolytic

Acts on spinal cord and subcortical levels by depressing polysynaptic reflexes

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15
Q

Cyclobenzaprine

A

Central spasmolytic

Reduces tonic somatic motor activity by influencing alpha and gamma motor neurons

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16
Q

Cyclobenzaprine side effects

A

Xerostomia

17
Q

Diazepam

A

Central spasmolytic

Promotes binding of major inhibitory NT in CNS y-GABA to a-GABA

Schedule IV controlled substance

18
Q

Tizanidine

A

Central spasmolytic

a2 agonist that decreases excitatory input to alpha motor neurons

19
Q

Danrolene

A

Non-central spasmolytic

Inhibits RyD receptor

Used to treat spasticity with UMN disorders

20
Q

Botulism

A

Treats stabismus, blepharospasm w/ dystonia, cervical dystonia, axillary hyperhidrosis, prophylaxis of chronic migraines

21
Q

Dantrolene side effect

A

Focal muscle weakness in areas of injection

22
Q

Glatiramer acetate

A

MS drug

Mixes random polymers of 4 AA to activate T cell suppressors specific for myelin Ag

23
Q

Interferon-B-1a and Interferon-B-1b

A

MS drug

acts on BBB interfering w/ T cell adhesion to endothelium by binding VLA-4 on T cells or by inhibiting T cell expression of MMP

24
Q

Mitoxantrone

A

MS drug and anti-neoplastic for prostate CA

intercalates into DNA resulting in cross link and strand break

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