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PHARM > DMARDs > Flashcards

DMARDs Flashcards

1
Q

First line treatment for RA

A

NSAIDs

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2
Q

Glucocorticoid used for RA

A

Prednisone

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3
Q

Methotrexate

A

DHF reductase inhibitor

MTX-(glu) acc. => block thymidylate synthase

AICAR acc. => GPCR => anti-inflammatory

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4
Q

Methotrexate side effect

A

Hepatic fibrosis

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5
Q

Hydrochloroquine

A

Increases pH of lysosome to 6

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6
Q

Hydrochloroquine side effect

A

retinal damage (rare)

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7
Q

Sulfasalazine

A

Metabolized to sulfapyridine and 5-ASA

Also used for IBD

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8
Q

Leflunomide

A

Inhibits dihydroorotate dehydrogenase

Inhibits T cell proliferation

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9
Q

Lefluomide side effects

A

Alopecia and SJS

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10
Q

Etanercept

“75 year olds go e-TANning 1-2x per week”

A

Bio-DMARD

p75 TNF receptor protein

SubQ 1-2x/week

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11
Q

Adalimumab

“Ada is the best, she recombines TNF to cure RA”

A

Recombinant fully human anti-TNF mAb

SubQ every 2 weeks

Best selling drug for RA and psoriatic arthritis

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12
Q

Infliximab

“Netflix has chimeric inflammatory shows every 6 weeks”

A

Chimeric mAb against TNF

IV every 6 weeks

Treats inflammatory arthritis and IBD

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13
Q

Rituximab

A

B-cell depleter (CD20 Ab)

IV every 6 weeks

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14
Q

Rituximab predict greater response

A

Positive RF or anti-CCP

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15
Q

Abatacept

“Bat at the T cell”

A

T-cell activation inhibitor
Soluble CTLA-4 and Fc portion of IgG1

Prevents CD28 binding CD80/86

Prevents collagen induced arthritis

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16
Q

Tocilizumab

“I’L take 6 Tacos”

A

Anti IL-6 antibody

IV monthly for one hour

17
Q

Tocilizumab side effect

A

URI, life threatening infections

18
Q

Tofactinib

“Eat tofu at JAK stack”

A

JAK3 inhibitor

Inhibits IL-17, IFN-y, CD4+ T cells

19
Q

Tofactinib side effect

A

Serious/fatal opportunistic infections

20
Q

Anakinra

A

Recombinant IL-1 antagonist; not really used and it’s a late choice

PHARM (4 decks)

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