Muscle Disorders & PNS

Question 1

Erb-Duchenne’s Muscular Dystrophy

Answer 1

0-12 y.o. boys, autosomal recessive, sever–>FATAL, pseudohypertorophy of calf muscles, increased CPK 300x “X-linked”, mother to son, pelvis & legs

Question 2

Becker Muscular Dystrophy

Answer 2

10-70 y.o., autosomal recessive, mild, less severe than Duchenne’s slower, pelvis & legs

Question 3

Facioscapulohumeral Dystrophy

Answer 3

10-20 y.o., autosomal dominant, mild, affects face & shoulders

Question 4

Myotonic Dystrophy

Answer 4

Adults, autosomal dominant, slow progression, affects face, tongue & extremities

Question 5

Guillain-Barre (Acute Demyelination Polyneuritis) (Landry’s Paralysis)

Answer 5

Acute polyneuropathy, polyradiculitis, following surgery or immunization, ASCENDING paralysis

Question 6

Myasthenia Gravis (Erb-Goldflam’s)

Answer 6

Female, myoneural junction, decrease acetylcholine receptors, especially the cranial nerves, ptosis, diplopia, eyes effected 1st

Question 7

Lambert-Eaton

Answer 7

Common with small cell carcinoma (lung), increased contractions with repeated stimuli

Question 8

Charcot-Marie-Tooth

Answer 8

Autosomal dominant, onset in childhood, calf muscle atrophy, demyelination, pain

Question 9

Ehlers-Danlos Syndrome

Answer 9

Autosomal dominant, hyper-extensible skin & joints, large artery FRAGILITY

Question 10

McArdle’s

Answer 10

30-40 y.o., myalgia, early fatigue, painful ramps, weakness of exercising muslces