Muscle Disorders

Question 1

Rhabdomyolosis

Answer 1

Muscle breakdown resulting in the release of myoglobin into extracellular space & bloodstream

Resulting in myoglobinemia> myoglobinuria

Question 2

Causes of Rhabdomyolosis

Answer 2

Trauma
Severe Compartment syndrome
Mediations
Infections/ inflammation

Question 3

Rhabdomyolosis Clinical Manifestations

Answer 3

Most severe complication is acute kidney injury due to flow obstruction in the nephron

The classic triad of symptoms is:
Muscle pain
Weakness
Dark urine

Question 4

Compartment Syndrome

Answer 4

Tissue pressure within a closed muscle compartment

Exceeds perfusion pressure  muscle and nerve ischemia

↓ O2 & ↑ waste products pain & peripheral sensation

If untreated:
Muscles & nerves undergo ischemic necrosis
Limb contracture
Renal failure & death

Question 5

Clinical Manifestations of Compartment (six P’s)

Answer 5

Pain (out of proportion to injury)
Pressure (from swelling)
Pallor
Parasthesia
Paresis
Pulselessness