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NYCC Cell Physiology > Muscle Cells and Contraction > Flashcards

Muscle Cells and Contraction Flashcards

1
Q

What is the functional unit of skeletal muscle?

A

Sarcomere

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2
Q

What is the I-band?

A

Actin only

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3
Q

What is the A-band?

A

Length of myosin (actin overlaps)

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4
Q

What is the H-band?

A

Myosin only

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5
Q

What is F actin?

A

Binding sites for myosin

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6
Q

What is tropomyosin?

A

Covers myosin binding sites

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7
Q

Location of Sarcomere

A

Z line to Z line

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8
Q

What is attached to the Z line?

A

Actin

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9
Q

What part of the Sarcomere changes in length?

A

H and I bands (gets shorter when actin slides over during contraction)

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10
Q

Troponin

A

When bound to Ca, causes a conformational change forcing tropomyosin into the groove, allows cross-bridge formation

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11
Q

Troponin I

A

Binds to actin

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12
Q

Troponin T

A

At the end of tropomyosin

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13
Q

Troponin C

A

Bind calcium

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14
Q

Myosin tail consists of…

A

2 heavy chains

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15
Q

Myosin head

A

4 light chains containing ATPase

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16
Q

Where is ATPase located in the Sarcomere?

A

Myosin head (light chains)

17
Q

2 accessory proteins

A

nebulin
Titin

18
Q

What connects thick filaments to the Z disc?

A

Titin

19
Q

What extends from the Z disc, adjacent to thin filaments?

A

Nebulin

20
Q

Sliding Filament theory steps

A
  1. relaxed state: Myosin head has ATP bound
  2. cross-bridge formation: ATPase converts ATP -> ADP+Pi
    a. Allows ‘high energy’ or ready position
    b. Ca ion influx allows cross-bridge formation (myosin binds to actin)
  3. power stroke: Release of Pi and ADP, actin slides over myosin
  4. End of contraction: Ca ions pumped back into SR and binding of ATP to myosin head dissociates actin & myosin
  5. ATP is hydrolyzed and myosin head resumes high energy conformation (back to step 1)
21
Q

Triad of skeletal muscle consists of…

A

T-tubule and 2 terminal cisternae

22
Q

T-tubule is ____ and transmits the ____

A

Sarcolemma
Action potential

23
Q

SR stores ____ with ____

A

Calcium
Calsequestrin

24
Q

Location of triad of skeletal muscle

A

AI junction

NYCC Cell Physiology (11 decks)

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